Results 81 to 90 of about 66,141 (268)

A Bayesian framework to estimate diversification rates and their variation through time and space [PDF]

open access: yes, 2011
Background: Patterns of species diversity are the result of speciation and extinction processes, and molecular phylogenetic data can provide valuable information to derive their variability through time and across clades.
Schnitzler, Jan   +8 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Supplementary Material: Robustness of Divergence Time Estimation Despite Gene Tree Error: A Case Study of Fireflies (Coleoptera: Lampyridae)

open access: yes, 2023
Supplementary Material for the manuscript "Robustness of Divergence Time Estimation Despite Gene Tree Error: A Case Study of Fireflies (Coleoptera: Lampyridae)"
Catalán, Ana   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Estimation for conditional moment models based on martingale difference divergence

open access: yes
We provide a new estimation method for conditional moment models via the martingale difference divergence (MDD). Our MDD-based estimation method is formed in the framework of a continuum of unconditional moment restrictions.
Song, Kunyang, Jiang, Feiyu, Zhu, Ke
core   +2 more sources

Phylogenetic placement of the mysterious Malagasy genus Ambrella H. Perrier (Vandeae, Orchidaceae)

open access: yesFrontiers in Plant Science
IntroductionThe monotypic genus Ambrella H. Perrier, endemic to Madagascar and traditionally placed within the subtribe Angraecinae, has long poses a challenge in terms of its phylogenetic classification.MethodsTo clarify the evolutionary position of ...
Sławomir Nowak   +4 more
doaj   +1 more source

Divergence Time Estimation of Aloes and Allies (Xanthorrhoeaceae) Based on Three Marker Genes

open access: yesDiversity, 2018
Aloes and allies are prominent members of African succulent vegetation and especially of the highly diverse Cape Flora. The main goal of this study was to obtain age estimates for alooids by calibrating a Bayesian phylogenetic analysis based on two ...
Zeinab Khodaei   +2 more
doaj   +1 more source

Estimating Divergence Times in the Presence of an Overdispersed Molecular Clock [PDF]

open access: yesMolecular Biology and Evolution, 2000
Molecular loci that fail relative-rate tests are said to be "overdispersed." Traditional molecular-clock approaches to estimating divergence times do not take this into account. In this study, a method was developed to estimate divergence times using loci that may be overdispersed.
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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