Results 91 to 100 of about 830,705 (276)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Optimal distribution of investments in a group of interconnected enterprises of the coal industry
Економіка, управління та адміністрування, 2019 The paper proposes a new approach to the distribution of investments in a group of coal mining enterprises. For the first time, the model for assessing the production efficiency of enterprises as a derivative of the level of resources attracted to the ...
O.M. Asheulova +3 more
doaj +1 more source
Jurnal Agrisep, 2015 Cassava, maize, and sweet potato are staple foods source diversification alternatives which are quite popular in society. But in terms of the efficiency of farming, it is still needed to study which farm remains profitable and has diversification ...
Putri Suci Asriani +2 more
doaj +1 more source
Technological Diversification and Strategic Alliances [PDF]
This paper examines empirically the relationship between the internal technological profile and the diversification through strategic alliances of the largest 219 industrial firms world-wide. It explores three related issues.
John Hagedoorn +2 more
core
Determinants of rural household income diversification in Senegal and Kenya [PDF]
, 2012 This paper investigates the determinants of income diversification using data on rural farm households from two Sub-Saharan African countries; Senegal and Kenya. Data were analyzed using regression techniques.
Alobo, Sarah
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
The Influence of Market Barriers and Farm Income Risk on Non-Farm Income Diversification [PDF]
Empirical evidence shows that non-farm income diversification is associated with higher welfare among farm households. However, most studies have ignored market barriers and farm income risk in explaining income diversification behaviour.
Nazli, Hina, Olale, Edward
core +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source