Results 71 to 80 of about 140,611 (264)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Unveiling seasonal variability in Crassostrea tulipa larval dispersal in Gulf of Guinea coastal waters: foundations for sustainable shellfish farming

Frontiers in Marine Science
The coastal zone of the Gulf of Guinea holds significant natural potential for the production of the mangrove oyster Crassostrea tulipa. This study assessed the larval dispersal of C. tulipa in the Benin’s coastal lagoon.
Yaovi Zounon, Yaovi Zounon, Dogbè Clément Adjahouinou, Dogbè Clément Adjahouinou, Pierrick Barbier, Sènakpon Emmanuel Wanou, Théophile Godome, Francina Moya-Ruiz, Manuel Vargas-Yáñez, Mari Carmen García-Martínez, Zacharie Sohou, Zacharie Sohou   +11 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The efficiency of chlorophyll fluorescence as a selection criterion for salinity and climate aridity tolerance in barley genotypes

Frontiers in Plant Science
IntroductionIn the Near East and North Africa (NENA) region, crop production is being affected by various abiotic factors, including freshwater scarcity, climate, and soil salinity. As a result, farmers in this region are in search of salt-tolerant crops
Zied Hammami, Soumaya Tounsi-Hammami, Nhamo Nhamo, Saleh Rezgui, Yousef Trifa   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

RESEARCHES CONCERNING PRODUCTION DIVERSIFICATION AND INTEGRATION IN ORDER TO INCREASE PROFITABILITY AND COMPETITIVENESS OF FAMILY SERICICULTURAL FARMS

Scientific Papers Animal Science and Biotechnologies, 2023
This study aimed to present different management variants for family sericicultural farms .These variants assures family reproduction sericicultural integrated management along production – processing – marketing chain, a larger range of marketable ...
AGATHA POPESCU, ALEXANDRA MATEI, VIORICA SLADESCU   +2 more
doaj  

Performance and internationalization effects of the use of ICT in diversified companies

Small Business International Review, 2018
The relationship between Information and Communication Technologies (ICT) and business performance has been a topic of great importance for academics from different areas for several decades.
Omar León, Juan Ignacio Igartua, Jaione Ganzarain   +2 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Diversification

, 2020
Chapter 4 asks the following question. With incessant infocap improvements, what would happen to consumer markets? We see that we can never attain perfect knowledge of the products; instead, enhanced selection power leads to product diversification. With the expanding set of consumer products, the expanding infocap, when spread over single items, would
Simmonds, Paul J., Sammut-Bonnici, Tanya, McGee, John, Cooper, Cary L.   +3 more
  +4 more sources