Results 71 to 80 of about 1,211,577 (349)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Recombination-aware phylogenetic analysis sheds light on the evolutionary origin of SARS-CoV-2

Scientific Reports
SARS-CoV-2 can infect human cells through the recognition of the human angiotensin-converting enzyme 2 receptor. This affinity is given by six amino acid residues located in the variable loop of the receptor binding domain (RBD) within the Spike protein.
Luis Roger Esquivel Gomez, Ariane Weber, Arthur Kocher, Denise Kühnert   +3 more
doaj   +1 more source

How Damage Diversification Can Reduce Systemic Risk

, 2015
We consider the problem of risk diversification in complex networks. Nodes represent e.g. financial actors, whereas weighted links represent e.g. financial obligations (credits/debts).
A. Garas, Antonios Garas, F. Schweitzer, Frank Schweitzer, G. Caldarelli, J. E. Stiglitz, M. E. J. Newman, P. Erdos, R. Cohen, R. Cont, Rebekka Burkholz   +10 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Genetic and Functional Diversification of Small RNA Pathways in Plants

PLoS Biology, 2004
Multicellular eukaryotes produce small RNA molecules (approximately 21–24 nucleotides) of two general types, microRNA (miRNA) and short interfering RNA (siRNA).
Zhixin Xie, Lisa K. Johansen, Adam M. Gustafson, K. Kasschau, Andrew D. Lellis, Daniel Zilberman, S. Jacobsen, J. C. Carrington   +7 more
semanticscholar   +1 more source

Diversification of Neotropical Freshwater Fishes

, 2020
Neotropical freshwater fishes (NFFs) constitute the most diverse continental vertebrate fauna on Earth, with more than 6,200 named species compressed into an aquatic footprint
J. Albert, Victor A. Tagliacollo, F. Dagosta   +2 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Assessment of the Growth of Juvenile Oysters Crassostrea tulipa (Lamarck, 1819) in the Coastal Waters of the Gulf of Guinea: Case of the Coastal Lagoon in Southern Benin

Oceans
The coastal zone of the Gulf of Guinea is characterised by the intensive harvesting of Crassostrea tulipa oysters, locally known as ‘Adakpin’ or ‘Atcha’, which serve as a vital source of income for local communities.
Yaovi Zounon, Zacharie Sohou, Manuel Vargas-Yáñez, Dogbè Clément Adjahouinou, Legrand Sylvère Debleo, Théophile Godome, Francina Moya Ruiz, M. Carmen García Martínez   +7 more
doaj   +1 more source

Towards a theory of regional diversification: combining insights from Evolutionary Economic Geography and Transition Studies

Transitions in Regional Economic Development, 2017
Towards a theory of regional diversification: combining insights from Evolutionary Economic Geography and Transition Studies. Regional Studies.
R. Boschma, Lars Coenen, K. Frenken, B. Truffer   +3 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source