, 2018 Poster for Poetry Workshop and Open Mic Event presented by the Diversity Center taking place in the DCSponsored ...
UWB Marketing
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Versed: Bulletin of the Office for Diversity
, 2006 March-April 2006 issue contains: Diversity research grant topics; Dollars for diversity campaign; Opening doors by Cooke; book review by Underhill; New voices by ...
Office for Diversity
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Integrated conservation of linear heritage landscapes from a biocultural diversity perspective: A case study of the Huizhou-Hangzhou Ancient Trail, China. [PDF]
PLoS OneDong Y, Pan C, Pan S, Zhang L.
europepmc +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Young Adults' Perspectives on Healthcare Workforce Diversity and Communication: Implications for Orthopedic Practice. [PDF]
Orthop Rev (Pavia)LaGrow T, Baer T, Viswanath O, Ganti L.
europepmc +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Exploring Genetic Polymorphism of <i>Plasmodium vivax</i> Variant Interspersed Repeats (<i>vir</i>) 12, Subfamily E, in Clinical Samples From Thailand. [PDF]
J Trop MedKuesap J, Suphakhonchuwong N.
europepmc +1 more source