Results 101 to 110 of about 173,483,608 (295)

Urban blue and green spaces: distribution, social equity, and ecological implications in Great Britain

npj Urban Sustainability
Cities are closely linked to the ‘triple planetary crisis’, climate change, pollution, and biodiversity loss, and urbanisation affects human physical and psychological health. Urban blue-green spaces can lessen impacts by regulating temperature and water,
Matthew C. Morgan, Rodney Forster, Charlotte R. Hopkins, Africa Gómez   +3 more
doaj   +1 more source

Research into the Influence Mechanisms of Visual-Comfort and Landscape Indicators of Urban Green Spaces

Land
Urban green spaces play a crucial role in providing social services and enhancing residents’ mental health. It is essential for sustainable urban planning to explore the relationship between urban green spaces and human perceptions, particularly their ...
Yumeng Meng, Jiaxuan Shi, Mei Lyu, Dong Sun, Hiroatsu Fukuda   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Impact of transforming karst mountainous forests into urban parks on plant diversity patterns

Ecology and Evolution
The conversion of urban montane forest resources into urban parks requires careful assessment to understand its impacts on plant diversity over time. This study aims to enhance urban biodiversity conservation strategies by analyzing how habitat type and ...
Weize Wang, Xiaoyan Gao, Chunhua Cen, Mengping Jian, Zijin Wang, Jingyi Yang   +5 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

UWB Walkout for Diversity Center

, 2015
Video of the 2015 protest walkout for the diversity center with students and faculty.Walkout ...
UWB Students
core  

Spaces for Economic Diversity [PDF]

, 2019
The discipline of architecture operates within the organizing structure of the economy and is directly influenced by its flows and cycles. The fabric of the city is often a product of profit-pursuing goals, resulting in spaces prioritizing exchanges ...
Zhang, Yuxun Emmeily
core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Avifaunal diversity in urban greenspaces within Cotabato city, Mindanao Island, Philippines

Journal of Threatened Taxa
Information about the diversity of avifauna in urban green spaces in the Philippines needs to be more extensive. More so, data on birds in green spaces of the country’s Bangsamoro Region in Muslim Mindanao (BARMM) remain largely unreported.
Joan Rhea Mae L. Baes, Peter Jan D. de Vera, John Paul A. Catipay, Marian Dara T. Tagoon, Elsa May Delima-Baron   +4 more
doaj   +1 more source