Results 111 to 120 of about 33,968 (135)

Diversity Oriented Synthesis: A Challenge for Synthetic Chemists

2006
This article covers the diversity-oriented synthesis (DOS) of small molecules in order to generate a collection of pure compounds that are attractive for lead generation in a phenotypic, high-throughput screening approach useful for chemical genetics and drug discovery programmes.
A, Bender, S, Fergus, W R J D, Galloway, F G, Glansdorp, D M, Marsden, R L, Nicholson, R J, Spandl, G L, Thomas, E E, Wyatt, R C, Glen, D R, Spring   +10 more
openaire   +2 more sources

Diversity‐Oriented Synthesis

2013
Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways.
TRABOCCHI, ANDREA, Stuart L. Schreiber, Kieron M. G. O’Connell, Warren R. J. D. Galloway, David R. Spring, John M. Knapp, Mark J. Kurth, Jared T. Shaw, Ashkaan Younai, Giovanni Muncipinto, Ohyun Kwon, Zhiming Wang, Matthew G. LaPorte, John R. Goodell, Sammi Tsegay, Peter Wipf, Viktor Krchňák, Nadĕžda Cankařová, Eric Marsault, Mark Dow, Francesco Marchetti, Adam Nelson, José Luis Medina Franco, Luca Mannocci, Eduard A. Sergienko, Susanne Heynen Genel, Hongyan Sun, CAVALIERI, DUCCIO, Carlotta De Filippo, Irene Stefanini, Jürgen Bajorath, Jeremy R. Duvall, Eamon Comer, Sivaraman Dandapani, Nicholas Hill, Lingyan Du, Qiu Wang   +36 more
openaire   +1 more source

Diversity oriented synthesis of benzoxazoles and benzothiazoles

Tetrahedron Letters, 2007
Abstract A combinatorial synthetic route yielding benzoxazoles and benzothiazoles is described. The use of o -halophenylisocyanides in the Ugi reaction (U-4CR) followed by a copper-catalyzed cyclization affords the benzoxazole as well as the benzothiazole moiety in good yield and high diversity.
Julia H. Spatz, Thorsten Bach, Michael Umkehrer, Julien Bardin, Günther Ross, Christoph Burdack, Jürgen Kolb   +6 more
openaire   +1 more source

The diversity‐oriented synthesis of pteridines—achievements and potential for development

IUBMB Life, 2013
AbstractThe importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged the development of the chemistry and chemical biology of pteridines. In order to investigate the latter, versatile synthetic methods are required to prepare designed relatives of the natural cofactors for use as potential drugs or ...
openaire   +4 more sources

Structural diversity-oriented synthesis

The DMP is focused on exploration of skeletal transformations of beta-caryophyllene, one of most accessible sesquiterpenes. This abundant natural product possesses cyclobutane and E-cyclononene fragments, which have an intrinsic aptitude to form other scaffolds under various reaction conditions.
openaire   +2 more sources

Some Principles of Diversity-Oriented Synthesis

2011
Chemical genetics has recently established itself as a systematic and powerful tool for exploring the biological world by exploiting the structural diversity of small molecules, notably with the aim of probing proteins (see chapter 2). Inhibiting the activity of a protein with a small molecule (a ligand) corresponds to eliminating the gene with which ...
openaire   +1 more source

A Modular Approach for Diversity‐Oriented Synthesis of 1,3‐trans‐Disubstituted Tetrahydroisoquinolines: Seven‐Step Asymmetric Synthesis of Michellamines B and C

Angewandte Chemie - International Edition, 2022
Hong-Gang Cheng, Qianghui Zhou
exaly  

Diversity-Oriented Synthesis

2012
Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O’Connell, David R. Spring   +6 more
openaire   +1 more source

A Planning Strategy for Diversity-Oriented Synthesis

Angewandte Chemie - International Edition, 2004
Martin Burke, Stuart Schreiber
exaly  

Anti‐MRSA Agent Discovery Using Diversity‐Oriented Synthesis

Angewandte Chemie - International Edition, 2008
David R Spring, Jodi Lindsay, Andreas Bender   +2 more
exaly