Results 71 to 80 of about 5,221,708 (261)

Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis

ChemistryEurope
Chemical libraries underpin contemporary drug discovery by enabling systematic exploration of chemical space for ligands. This review summarizes practical principles for designing, comparing, and selecting libraries, emphasizing how “diversity” can be ...
Tobias N. Hansen, Nils J. V. Hansen
doaj   +1 more source

Stereodivergent Diversity Oriented Synthesis of Piperidine Alkaloids

European Journal of Organic Chemistry, 2006
AbstractAlkylidenetitanium reagents enable the reagent‐controlled high throughput asymmetric synthesis of 2‐substituted piperidines and rapid access to multiple cyclic imines using solid phase synthesis (SPS). The Schrock carbenes, generated by reduction of thioacetals, convert resin‐bound esters into enol ethers.
Louis Adriaenssens, Carolyn A. Austin, Mairi Gibson, David Smith, Richard C. Hartley   +4 more
openaire   +3 more sources

Optical Signature of Moiré Superlattices Formed by Twisted SrTiO3 Membranes

Advanced Functional Materials, EarlyView.
We discover optical signatures from bonded interfaces in twisted SrTiO3 moiré superlattices, including low‐frequency Raman vibrational modes and strong second‐harmonic generation, consistent with strong interlayer coupling inferred from cross‐sectional electron microscopy and ab initio calculations. ABSTRACT Moiré superlattices formed at the interfaces
T. A. M. Ragib Shahriar, Fumikazu Murakami, Xing He, Konnor Koons, Xinyan Li, Bumseop Kim, Shihan Qin, Varun Harbola, Jochen Mannhart, Yimo Han, Ruijuan Xu, Shengxi Huang, Andrew M. Rappe, Hanyu Zhu   +13 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Diversity-Oriented Polymerization: One-Shot Synthesis of Library of Graft and Dendronized Polymers by Cu-Catalyzed Multicomponent Polymerization

, 2016
Graft and dendronized polymers have attracted much attention in the polymer community, and there have been significant efforts to develop better synthetic methods.
Jin-Kyung Lee (2862380), Tae-Lim Choi (1500892), Hyunseok Kim (122083), Ki-Taek Bang (1666684), Inho Choi (158094)   +4 more
core   +1 more source

Diversity oriented total synthesis (DOTS) of pyridoquinazolinone alkaloids and their analogues

Tetrahedron Chem
A short diversity oriented total synthesis (DOTS) of substituted rutaecarpines, homo-luotonins, homo-vasicinone, homo-isaindigotones and homo-vasnetine has been achieved from the key tricyclic intermediate.
Sivappa Rasapalli, Yanchang Huang, Vamshikrishna Reddy Sammeta, Reem Alshehry, Fazmina Anver, James A. Golen, Shivasankar Krishnamoorthy, Subhash P. Chavan   +7 more
doaj   +1 more source

Two‐Photon Grayscale Lithography (2GL) of High Mechanical and Optical Quality 3D Silica Glass Microstructures

Advanced Functional Materials, EarlyView.
Two‐photon grayscale lithography (2GL) enables high‐speed and precise 3D printing of thermolyzed silica glass microstructures with optical‐grade surface quality, high quality factors, and mechanical strength utilizing a custom‐made pre‐glass resist based on polyhedral oligomeric silsesquioxane (POSS) modified with a high‐sensitivity Norrish type II ...
Jonathan L. G. Schneider, Jiajie Liang, Paul Somers, Martin Wegener, Jens Bauer   +4 more
wiley   +1 more source

Strong Lead‐Free Bioinspired Piezoceramics for Durable Energy Transducers

Advanced Functional Materials, EarlyView.
We fabricated brick‐and‐mortar lead‐free piezoceramics with Bi0.5Na0.5TiO3 monocrystal platelets as bricks and amorphous silica as mortar. The alignment of the bricks and the presence of the amorphous silica led to anisotropic residual stresses. These residual stresses increase the samples toughness, strength and durability while the brick alignment ...
Ruxue Yang, Temesgen Tadeyos Zate, Peiren Wang, Soumyajit Mojumder, Elo Overgaard Mogensen, Oriol Gavalda‐Diaz, Zihe Li, Shitong Zhou, Ajeet Kumar, James Roscow, Hamideh Khanbareh, Astri Bjørnetun Haugen, Florian Bouville   +12 more
wiley   +1 more source

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

, 2018
Over the past few decades, hit identification has been greatly facilitated by advances in high-throughput and fragment-based screenings. One major hurdle remaining in drug discovery is process automation of hit-to-lead (H2L) optimization. Here, we report
Alexandre Varnek (1425595), Sébastien Combes (1444012), Brigitt Raux (1444024), Philippe Roche (252076), Carine Derviaux (1444027), Stéphane Betzi (1444042), Laurent Hoffer (1967848), Xavier Morelli (252071), Yves Collette (135065), Yuliia V. Voitovich (5439104), Kendall Carrasco (5439110), Dragos Horvath (1425592), Agnès Amouric (5439101), Aleksey Y. Fedorov (5439107), Christophe Muller (2009851)   +14 more
core   +1 more source

Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction

Nature Communications, 2016
Diversity-oriented synthesis is useful for generating complex molecular structures occupying diverse molecular space. Here the authors report a strategy to access libraries of privileged heterocyclic structures, and furthermore identify an inhibitor of ...
Jonghoon Kim, Jinjoo Jung, Jaeyoung Koo, Wansang Cho, Won Seok Lee, Chanwoo Kim, Wonwoo Park, Seung Bum Park   +7 more
doaj   +1 more source