Results 31 to 40 of about 807,944 (257)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Orientalism at work?: Dundee’s response to competition from Calcutta, circa 1870-1914 [PDF]
, 2014 From the late nineteenth century the Dundee jute industry faced intensifying competition from Calcutta. This article examines the responses in Dundee to this competition, focusing upon the ways Dundonians understood Calcutta and India, and how these ...
Tomlinson, James
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Cambio, 2021 Current diversity and anti-discrimination policies are the result of intended and non-intended long-term social movements and changes. This implicates informalisation processes as well as formalisation processes of organizations, in which sexism, racism,
Stefanie Ernst
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Public School Politics: A Review of The End of Consensus
Southern Spaces, 2016 Karen Pooley reviews Toby L. Parcel and Andrew J. Taylor's The End of Consensus: Diversity, Neighborhoods, and the Politics of Public School Assignments (Chapel Hill: The University of North Carolina Press, 2015).
Karen Pooley
doaj +1 more source
The politics of equality and diversity in Higher Education [PDF]
, 2012 The aim of this paper is to provide an exploration of the perspectives relating to equality, diversity and anti-discrimination legislation from multi-actors at different levels of seniority and with varying involvement with equality issues and diversity ...
Crofts, Melanie, Pilkington, Andrew
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Democracy, Race, and Multiculturalism in the Twenty-First Century: Will the Voting Rights Act Ever be Obsolete? [PDF]
, 2006 Part I of this essay begins one hundred years before the passage of the Act, with Reconstruction. I briefly canvas the interracial alliances of the Reconstruction and Redemption periods, underscoring that American democracy has been most responsive to ...
Cashin, Sheryll
core +2 more sources