Results 41 to 50 of about 802,316 (308)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

Building an All-In Nation: A View from the American Public [PDF]

open access: yes, 2013
As shown throughout this report, Americans are much more open to diversity and more supportive of steps to reduce racial inequalities than is commonly portrayed in politics and the media.
Adrian Pantoja   +3 more
core  

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Convergence Across Difference: Understanding the Political Ties That Bind with the 2016 National Asian American Survey

open access: yesRSF: The Russell Sage Foundation Journal of the Social Sciences, 2021
Increased diversity has accompanied dramatic demographic growth of the Asian American population in recent years. If the common characteristic of Asian Americans is a diversity of origins, languages, resources, and cultural traits, what holds this group ...
Janelle Wong, Sono Shah
doaj   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

open access: yesFEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar   +3 more
wiley   +1 more source

Ulama dan Politik: Keterlibatan Ulama Sumatera Selatan dalam Politik Praktis dan Community Empowerment Pada Abad XX

open access: yesJurnal Studi Sosial dan Politik, 2017
The cleric of South Sumatra is a central figure who has a very wide authority. They have a multifunction with polymorphic leadership. Historical facts show that they are civilization actors who respond to various problems of South Sumatra in the ...
Nurseri Hasnah Nasution
doaj   +1 more source

Building China: Informal Work and the New Precariat [PDF]

open access: yes, 2015
[Excerpt] This book makes three main contributions to our understanding of informal work in China. First, it documents diversity in employment relations and the labor market.
Swider, Sarah
core   +1 more source

Heterogeneity, Politics of Ethnicity, and Multiculturalism What is a Viable Framework for Indonesia? [PDF]

open access: yes, 2011
Indonesia is a plural society that consists of several hundred ethnic and sub-ethnic groups. One of its generic characteristics is heterogeneity. In the last ten years after the implementation of regional autonomy, we have witnessed the emergence of ...
Lan, T. J. (Thung)
core   +3 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

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