Results 91 to 100 of about 10,260 (285)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Towards deep-learning (DL) based fully automated target delineation for rectal cancer neoadjuvant radiotherapy using a divide-and-conquer strategy: a study with multicenter blind and randomized validation. [PDF]

Radiat Oncol, 2023
Geng J, Zhu X, Liu Z, Chen Q, Bai L, Wang S, Li Y, Wu H, Yue H, Du Y.   +9 more
europepmc   +1 more source

Characterizing and Defending Against Divide-Conquer-Scanning Worms

, 2010
Internet worms are a significant security threat. Divide-conquer scanning is a simple yet effective technique that can potentially be exploited for future Internet epidemics.
Chen, Chao, Chen, Zesheng, Li, Yubin
core  

A Flexible Divide-And-Conquer Protocol for Multi-View Peer-to-Peer Live Streaming [PDF]

, 2009
Multi-view peer-to-peer (P2P) live streaming systems have recently emerged, where a user can simultaneously watch multiple channels. Previous work on multi-view P2P streaming solves the fundamental inter-channel bandwidth competition problem at the ...
Wang, Miao, Byrav Ramamurthy, Miao Wang, Lisong Xu, Xu, Lisong, Ramamurthy, Byrav   +5 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

An Intelligent Power Transformers Diagnostic System Based on Hierarchical Radial Basis Functions Improved by Linde Buzo Gray and Single-Layer Perceptron Algorithms

Energies
Transformers are fundamental and among the most expensive electrical devices in any power transmission and distribution system. Therefore, it is essential to implement powerful maintenance methods to monitor and predict their condition.
Mounia Hendel, Imen Souhila Bousmaha, Fethi Meghnefi, Issouf Fofana, Mostefa Brahami   +4 more
doaj   +1 more source