Results 101 to 110 of about 17,679 (280)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Efficient Square-Based Montgomery Multiplier for All Type C.1 Pentanomials
IEEE Access, 2018 In this paper, we present a low complexity bit-parallel Montgomery multiplier for $GF(2^{m})$ generated with irreducible Type C.1 pentanomials $x^{m}+x^{m-1}+x^{k}+x+1$ . Based on a combination of generalized polynomial basis (GPB) squarer and a newly
Yin Li, Xingpo Ma, Qing Chen, Chuanda Qi
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Columbia Journal of Race and Law, 2019 This Essay proposes to use the theoretical framework of Critical Race Theory and Marxism to chart a way forward and away from the Tea Party’s racist dream and toward revolution.
Bekah Mandell
doaj +1 more source
An Asymptotic Theorem for Multi-term Divide-and-Conquer Sequences Assuming a d-Condition
, 2021 Divide-and-conquer is a popular strategy to design algorithms. It splits the input into several smaller subproblems, solving each subproblem separately, and then combine together to solve the original problem.
Guedj, Michael
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Statistically consistent divide-and-conquer pipelines for phylogeny estimation using NJMerge
Algorithms for Molecular Biology, 2019 Background Divide-and-conquer methods, which divide the species set into overlapping subsets, construct a tree on each subset, and then combine the subset trees using a supertree method, provide a key algorithmic framework for boosting the scalability of
Erin K. Molloy, Tandy Warnow
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Divide and conquer? Size adjustment with allometry and intermediate outcomes
BMC Biology, 2017 Many trait measurements are size-dependent, and while we often divide these traits by size before fitting statistical models to control for the effect of size, this approach does not account for allometry and the intermediate outcome problem. We describe
Shinichi Nakagawa +4 more
doaj +1 more source