CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Divide and Conquer: A Simple, Modern Technique for Collaborative Small Group Learning with Reciprocal Peer Teaching. [PDF]
J Microbiol Biol Educ, 2021 Samsa LA, Goller CC.
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Divide and conquer approach for genome-wide association studies. [PDF]
GeneticsÖzkaraca Mİ +3 more
europepmc +1 more source
Unscented Particle Filter Algorithm Based on Divide-and-Conquer Sampling for Target Tracking. [PDF]
Sensors (Basel), 2021 Du S, Deng Q.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Automatic Parallelization of Divide--and--Conquer Algorithms
, 2007 . In this paper we present a system that automatically partitions sequential divide--and--conquer algorithms programmed in C into independent tasks, maps these to a MEIKO transputer system and executes them in parallel. The feasibility of our approach is
Thilo Kielmann, Bernd Freisleben
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A divide-and-conquer approach to uncover the genomic structure of the highly virulent RA strain of Trypanosoma cruzi. [PDF]
Sci RepBalouz V +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Abstract Architecture-Cognizant Divide and Conquer Algorithms £
, 2008 Divide and conquer programs can achieve good performance on parallel computers and computers with deep memory hierarchies. We introduce architecture-cognizant divide and conquer algorithms, and explore how they can achieve even better performance.
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