Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
LHA-YOLO: A Lightweight and High-Accuracy Detector via Parallel Attention and Divide-and-Conquer Fusion for UAV Images. [PDF]
Sensors (Basel)Yang J, Pan X, Pan Q.
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
deMEM: a novel divide-and-conquer framework based on de Bruijn graph for scalable multiple sequence alignment. [PDF]
GigascienceWei Y +6 more
europepmc +1 more source
A Divide-and-Conquer Bat Algorithm with Direction of Mean Best Position for Optimization of Cutting Parameters in CNC Turnings. [PDF]
Comput Intell Neurosci, 2022 Huang X, He Z, Chen Y, Xie S.
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Divide and Conquer In Reliability Analyses
, 2009 All product is not created equal. Some units are more likely to fail in service than others. Thus, in reliability evaluations, you need to identify subpopulations with different failure susceptibility.
Doganaksoy, Necip +2 more
core
A universal "Divide-and-conquer, precise reconstruction" strategy: Multiscale simulation-guided high-fidelity restoration and controlled release of rose aroma. [PDF]
Curr Res Food SciLiu C +8 more
europepmc +1 more source
A divide-and-conquer phylogenomic approach based on character supermatrices resolves early steps in the evolution of the Archaea. [PDF]
BMC Ecol Evol, 2022 Aouad M +5 more
europepmc +1 more source