Results 51 to 60 of about 4,897,555 (276)
FEBS Letters, EarlyView.Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley +1 more source
Viscovatov-Like Algorithm of Thiele–Newton’s Blending Expansion for a Bivariate Function
Mathematics, 2019 In this paper, Thiele−Newton’s blending expansion of a bivariate function is firstly suggested by means of combining Thiele’s continued fraction in one variable with Taylor’s polynomial expansion in another variable.
Shengfeng Li, Yi Dong
doaj +1 more source
A divided differences based medium to analyze smoothness of the binary bivariate refinement schemes
Advances in Difference Equations, 2021 In this article, we present the continuity analysis of the 3D models produced by the tensor product scheme of ( m + 1 ) $(m+1)$ -point binary refinement scheme.
Rabia Hameed +3 more
doaj +1 more source
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Semi-classical Orthogonal Polynomial Systems on Non-uniform Lattices, Deformations of the Askey Table and Analogs of Isomonodromy [PDF]
, 2012 A $\mathbb{D}$-semi-classical weight is one which satisfies a particular linear, first order homogeneous equation in a divided-difference operator $\mathbb{D}$.
Witte, N. S.
core
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
On the Leibniz formula for divided differences
Journal of Numerical Analysis and Approximation Theory, 2006 We give an identity for the Hermite-Lagrange interpolating polynomial and a short proof of Leibniz-type formula for divided differences in case of coalescing knots.
Mircea Ivan
doaj +2 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source