Results 121 to 130 of about 108,961 (314)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Perichoretic Persons: Diagramming Augustine’s Mental Trinity
Perichoresis: The Theological Journal of Emanuel UniversityThis article seeks to develop new insight from De Trinitate into what it means to be a trinitarian person by diagramming the interchange of cognition and love that Augustine traces in the mental trinity.
Adams Nathan A.
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Chimes of truth; or Divine metaphysics ...
, 1937 Mode of access ...
Society of Divine Metaphysics. +1 more
core
The study aimed to examine the influence of attitude toward work on the organizational commitment of employees. To deepen the concept of the study, literatures were reviewed. The study applied descriptive assessment and correlational research design. The
Marlene T. Nicolas +7 more
core +1 more source
Accommodation, Fortification, or Conversion? Approaches to Catholic Engagement with Secular Culture
ReligionsAs the Catholic Church declines in the west, critical questions are raised about its engagement with secular culture. Different engagement models have been experimented with since the 1960s, which I term accommodation, fortification, and conversion. Each
Hannah Vaughan-Spruce
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Serum aberrant expression of microRNA-125b-5p and its association with carotid artery stenosis
Türk Biyokimya DergisiThis study focused on the aberrantly expressed miR-125b-5p and explored its diagnostic and prognostic value in CAS patients.
Guo Xiaoling +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source