Results 61 to 70 of about 27,799 (249)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Ludwig von Mises’s Praxeology as the Foundation of Christian Economic Personalism
Studies in Logic, Grammar and Rhetoric, 2019 What can an economist and agnostic tell a theologian about man? In contrast to mainstream economics, which today dominate all universities in the world, Ludwig von Mises (+1973) is interested in real man in action, not a fictitious homo oeconomicus.
SVD Jacek Gniadek
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
From the Ultimate God to the Virtual God: Post-Ontotheological Perspectives on the Divine in Heidegger, Badiou, and Meillassoux [PDF]
Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2014 The Heideggerian account of the ontotheological constitution of Western metaphysics has been extremely influential for contemporary philosophy of religion and for philosophical perspectives on theology and the divine.
Jussi Backman
doaj
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
SAGE Open, 2015 For more than a century, there has been an ongoing paradigm debate between qualitative and quantitative methodological communities that has led to a growing interest in the mixed methods approach.
Iwona Kolodziejczyk
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Fırat Üniversitesi İlahiyat Fakültesi Dergisi, 2014 Büyük Türk Mutasavvıf-Şâiri Yûnus Emre’nin hayatı gibi mûsikî yönüne dâir bilgiler de oldukça sınırlıdır. Ancak buna rağmen hakkında en fazla söz söylenen ve akademik çalışma yapılan şahsiyetlerin başında yer almaktadır.
Yavuz Demirtaş
doaj