Results 221 to 230 of about 348,820 (310)

Achieving our highest potential through character development (Husn-i-Akhlaaq): an Islamic perspective on holistic personality development, spiritual growth and human flourishing. [PDF]

Front Psychol
Gillani U, Khan MJ.
europepmc   +1 more source

Neoclassical special divine action

, 2019
openaire   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Characterizing the Multidimensional Relationship Between Spirituality and Obsessive-Compulsive Disorder: Thematic Analysis. [PDF]

JMIR Form Res
Sun NY, Guerra SE, Patil MM, Chakravadhanula SS, Pittenger C, Ching T.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

The role of community co-designed interventions for malaria prevention and control in conflict-affected communities in Cameroon's Southwest and littoral regions. [PDF]

Malar J
E O EBM, Yankam BM, Ogundeko-Olugbami O, Donovan L, Counihan H, Hawkings H, Maxwell K, Baker K, Zoungrana Y, Tanue EA, Noukeme BM, Metuge A, Nganmou I, Divine A, Coril E, Gilbert K, Sachop N, Ako S, Pensha J, Tabong AO, Itoe BT, Wanji S, Berryman E, Jarman E, Omam EN, Omam LA.   +25 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A protocol for a systematic review of the psychosocial effects of experiencing compassion from others and its interpretation through secular and religious frameworks. [PDF]

Syst Rev
Lazzari C, Crawford P, Ashmore A, Kotera Y.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mystics and politics: women and the interpretation of the Scriptures. [PDF]

Semiotica
Ponzo J.
europepmc   +1 more source