Results 91 to 100 of about 144,792 (309)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The Mystery of Awe and Silence at the Level of the Uniqueness of Divine Essence: The Views of Avicenna, Mullā Ṣadrā, and ʿAllāma Ṭabāṭaāʾī [PDF]
حکمت معاصرIn their theological works, Muslim philosophers tend to elaborate on the unity and other attributes of the Necessary Existent (wājib al-wujūd) after establishing its existence. In such discussions, they examine the essence (dhāt) alongside its attributes
Fatemeh Sadeqzadeh Qamsari
doaj +1 more source
Heroical Apatheism: Mala Fide Bootstrapping Obligations [PDF]
, 2018 Discussions on hypothetical gods virtually always focus on the latter’s existence or nonexistence. However, this is only the secondary question. Heroical apatheism distinguishes these questions from the primary question, which pertains to the importance ...
Von Hegner, Ian
core +1 more source
Nestes Modes, ’Qua’ and the Incarnation [PDF]
, 2014 A nested mode ontology allows one to make sense of apparently contradictory Christological claims such as that Christ knows everything and there are some things Christ does not ...
Pruss, Alexander R.
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Theological and rhetorical point of view of theologians (Ash'arites and Mu'tazilites)
مطالعات تطبیقی فقه و اصول مذاهب, 2019 This word, with its two types - spiritual and pronounced - has different definitions and interpretations from the perspective of different schools and religions, and it can be said that these definitions imply the importance of a subject that is hidden ...
Sajed Adak
doaj +1 more source
, 2015 This paper explores different readings of Spinoza\u27s Ethics with a specific focus on Spinoza\u27s understanding of the relationship between infinite and finite modes in his constructed universe.
Horvath, Jeffrey J.
core
Animals and the Problem of Evil in Recent Theodicies [PDF]
, 2009 This paper critically evaluates the theodicies of John Hick, Richard Swinburne and process theism regarding animal suffering and evils. The positions of Hick and Swinburne are based on false empirical assumptions, e.g., animals do not suffer.
Maller, Mark
core +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source