Results 71 to 80 of about 144,792 (309)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Ethics from the Viewpoint of Asharites and Separatists [PDF]
اخلاق وحیانی, 2013 Ethics is about good and evil and it constantly circles around these two issues whether when it is discussed with regard to beliefs or sensual qualities or deeds.
Hamid Malekmakan
doaj
Theōsis: A Comparative Study of T. F. Torrance and Rāmānuja [PDF]
, 2017 This essay is an imaginative conversation as I engage two religious thinkers—the prolific Reformed theologian Thomas F. Torrance (1913-2007) and the great Vedāntin Rāmānuja (traditionally, 1017–1137).
Tsoukalas, Steven
core +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Aquinas' Counterfactual Incarnations
TheoLogicaThis paper is an examination of Aquinas’ account of the various ways in which the Incarnation might have occurred. Aquinas maintains that the Son of God became incarnate by assuming a specific body/soul union.
Christopher Hughes Conn
doaj +1 more source
The Essence or Existential Challenge of the Will of God from Imam Reza’s Viewpoint according to Mulla Sadra’s Philosophical Interpretation with Criticism of Allameh Tabataba'i’s Theory [PDF]
آموزههای فلسفه اسلامي, 2020 One of the most important issues in the Shi'ite theological foundations is divine attributes which is mentioned in various Qur'anic verses with different names and attributes. According to rational arguments and narrated hadiths; divine attributes are of
Asmaa Ahmadi, Mahmoud Saidi
doaj
Trajectories in the Development of Islamic Theological Thought: the Synthesis of Kalam [PDF]
, 2007 The field of Islamic theology (kalam) is not merely a receptacle for the presentation of the creedal statements and doctrinal catechisms of Islam; it derives its raison d’être not only from the articulation and elucidation of the doctrines of faith, but ...
Shah, Mustafa
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source