Results 51 to 60 of about 2,768 (258)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Aquinas' Counterfactual Incarnations

open access: yesTheoLogica
This paper is an examination of Aquinas’ account of the various ways in which the Incarnation might have occurred. Aquinas maintains that the Son of God became incarnate by assuming a specific body/soul union.
Christopher Hughes Conn
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Ethics from the Viewpoint of Asharites and Separatists [PDF]

open access: yesاخلاق وحیانی, 2013
Ethics is about good and evil and it constantly circles around these two issues whether when it is discussed with regard to beliefs or sensual qualities or deeds.
Hamid Malekmakan
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Theology of Divine Laughter: A Superiority Theory Analysis of Ḍaḥik Allāh in Hadith and Its Theological Implications

open access: yesJurnal Keislaman
This research examines the attribute of divine laughter (ḍaḥik Allāh) from the perspective of prophetic traditions (ḥadīth) through the lens of Superiority Theory.
Andi Mustopa   +4 more
doaj   +1 more source

A Critical Assessment of Negative Theology of Dionysus in the Light of Quran and Prophetic Traditions [PDF]

open access: yesComparative Theology, 2013
The most important aspect of divine names and attributes is their semantics. Human beings’ interpretation of this aspect will have a profound impact on the type of relationship they have with God as it is by these names and attributes that we know God ...
Abouzar Nourouzi, ٍReza Berenjkar
doaj  

The Essence or Existential Challenge of the Will of God from Imam Reza’s Viewpoint according to Mulla Sadra’s Philosophical Interpretation with Criticism of Allameh Tabataba'i’s Theory [PDF]

open access: yesآموزه‌‌های فلسفه اسلامي, 2020
One of the most important issues in the Shi'ite theological foundations is divine attributes which is mentioned in various Qur'anic verses with different names and attributes. According to rational arguments and narrated hadiths; divine attributes are of
Asmaa Ahmadi, Mahmoud Saidi
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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