Results 51 to 60 of about 201,281 (315)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Virtue of Understanding God as Almighty
ReligionsGod’s power is usually discussed in terms of omnipotence. However, the problems associated with omnipotence are complex, and even if some think that the problems are resolvable, many find the purported resolutions unsatisfactory.
Bruce R. Reichenbach
doaj +1 more source
ETIKA PROFETIK BAGI PENGELOLA KEUANGAN NEGARA [PDF]
Jurnal Akuntansi Multiparadigma, 2019 : Prophetic Ethics for State Financial Managers. This article aims to develop the concept of prophetic ethics by using local wisdom of Malay culture. The principles of social science and prophetic spirit are used as methods.
Bobby Briando , Agung Sulistyo Purnomo
doaj +1 more source
Recognizable Goodness”: A Response to Beversluis’ Understanding of God’s Goodness
, 2016 In her rebuttal to John Beversluis’ C. S. Lewis and the Search for Rational Religion, Emily McCarty makes the following arguments. Lewis maintains throughout these three works that God’s goodness is recognizable. In The Problem of Pain, what seems unlike
McCarty, Emily
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
The Transcendentals and the Divine Names in Thomas Aquinas
, 2018 Interpreters of Aquinas tend to posit a seamless transition from knowledge of the transcendentals in the abstract to naming God as one, true, and good. Some even suggest that the convertibility of the transcendentals with being implies the unity, truth ...
null null, Brian T. Carl
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
, 2016 In conversation with the essays by Jeffery Long and Klaus von Stosch, Wendy Farley interrogates theology itself as a source of evil. This essay argues that defense of free will as the basis of theodicy obscures the arbitrary and bound nature of human ...
Wendy Farley
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source