Results 91 to 100 of about 4,303,518 (344)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

“The Road of Payback” and Rabbinic Judaism

open access: yesReligions, 2019
In Anger and Forgiveness, Martha Nussbaum argues against the claim that the suffering of the wrongdoer restores, or partially restores, what was damaged by the wrongdoing. Making this mental mistake sets a person on “the road of payback,” and
Jonathan Schofer
doaj   +1 more source

The Principle of Analogy [PDF]

open access: yes, 2006
The Principle of Analogy. ABSTRACT. Sceptics question whether ‘distinctively human’ predicates such as ‘just’, ‘loving’ and ‘powerful’ can intelligibly be attributed to a divine being.
Bunting, Harry
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Hieroglyphiskt i Stockholms slott omkring 1900

open access: yesICO Iconographisk Post, 2021
This paper deals with some themes composed by and for King Oskar II in the Royal Palace in Stockholm. Three paintings in the ceiling of the King’s staircase depict Society andSweden, the Cosmos and the Transfiguration. They
Bo Vahlne
doaj  

Chance in a Created World: How to Avoid Common Misunderstandings about Divine Action [PDF]

open access: yes, 2015
In the article ”Against Physicalism-plus-God: How Creation Accounts for Divine Action in the World’, I defined a framework which allows us to make some progress in our understanding of how God acts in the world.
Jaeger, Lydia
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

THE REFLECTION OF PANTHEISM’S PRINCIPLES OF IBN ARAB IN AHMED KHANI'S WORKS"

open access: yesگۆڤارا زانستێن مرۆڤایەتی یا زانكۆیا زاخۆ
The concept of pantheism is among the most profound and influential intellectual theories in Islamic mysticism, particularly within Sufism. The idea of pantheism, which reached its pinnacle in the works of the Andalusian Mystic Ibn Arab (1164–1240 CE ...
Waheed Ramadhan, Shvan Hassan
doaj   +1 more source

Divine Light and Melodies Lead the Way: The Santmat Tradition of Bihar

open access: yesReligions, 2019
This paper focuses on the branch of Santmat (thus far, unstudied by scholars of Indian religions), prevalent in the rural areas of Bihar, India. Santmat—literally meaning “the Path of Sants„ or “Point of View of the Sants„ ...
Veena R. Howard
doaj   +1 more source

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