Results 91 to 100 of about 345,532 (386)

Possibilities of Inner Ear Barrier Models for Otologic Drug Development

Advanced Therapeutics, EarlyView.
This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn, Seonmin Choi, Minju Kim, Zachary Estlack, Daniel Brown, Jaehong Key, Young Joon Seo, Jungkyu Kim   +7 more
wiley   +1 more source

Vestibular function tests are helpful in differentiating between Menière’s disease and vestibular migraine

Frontiers in Neurology
AimMenière’s disease (MD) presents with episodic vertigo and auditory symptoms. Vestibular migraine (VM) typically contains migraine features associated with the vertigo attacks.
Eleonora G. M. Vosbeek, Eleonora G. M. Vosbeek, Meinie Seelen, Aliede M. Vingerhoed, Tjard R. Schermer, Tjard R. Schermer, Suzanne C. Cannegieter, Suzanne C. Cannegieter, Gisela M. Terwindt, Tjasse D. Bruintjes, Tjasse D. Bruintjes   +10 more
doaj   +1 more source

Benign paroxysmal positional vertigo, dizziness, and health-related quality of life among older adults in a population-based setting

European Archives of Oto-Rhino-Laryngology, 2020
Purpose Dizziness may affect quality of life in a negative way and contribute to falls. The aim of this study was to investigate and compare 75 years old with dizziness caused by benign paroxysmal positional vertigo (BPPV) to those with general dizziness/
E. Lindell, L. Kollén, Mia Johansson, Therese Karlsson, L. Rydén, Hanna Falk Erhag, H. Wetterberg, A. Zettergren, I. Skoog, C. Finizia   +9 more
semanticscholar   +1 more source

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

Advanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring, Brian P. Conlon, Edward A. Miao, Blossom Damania, Anna Mae Diehl, Pengda Liu   +14 more
wiley   +1 more source

Advanced Image‐Guidance and Surgical‐Navigation Techniques for Real‐Time Visualized Surgery

Advanced Science, EarlyView.
This review comprehensively summarizes advances in surgical navigation, covering both established and emerging intraoperative imaging technologies. It highlights mechanisms, advantages, limitations, and clinical applications, while emphasizing interdisciplinary collaboration.
Xiaoxiao Fan, Xiaolong Liu, Qiming Xia, Guoqiao Chen, Jiaxi Cheng, Zhaoqi Shi, Yifeng Fang, Parikshit Asutosh Khadaroo, Jun Qian, Hui Lin   +9 more
wiley   +1 more source

Altered Regional Cerebral Blood Perfusion in Mild Cognitive Impairment Patients with Dizziness

Diagnostics, 2020
Dizziness is a common symptom among the general population, especially in the elderly. Previous studies have reported that dizziness may be associated with various cognitive functions including memory impairment.
Seunghee Na, Jooyeon Jamie Im, Hyeonseok Jeong, Eek-Sung Lee, Tae-Kyeong Lee, Yong-An Chung, In-Uk Song   +6 more
doaj   +1 more source

The clinical pharmacology of intranasal l-methamphetamine. [PDF]

, 2008
BackgroundWe studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.Methods12 subjects self-administered l-methamphetamine from a nonprescription inhaler at the recommended dose (16 inhalations over 6 ...
Everhart, Tom, Foster, Elyse, Harris, Debra S, Jacob, Peyton, Jones, Reese T, McGlothlin, Dana, Mendelson, John E   +6 more
core   +2 more sources

A Programmable, 3D Neuron‐On‐Chip Platform Integrating Near Real‐Time Biosensing and Multiaxial Loading for Mechanobiological Injury Profiling

Advanced Science, EarlyView.
A programmable 3D Neuron‐Injury‐on‐a‐Chip platform integrates multiaxial mechanical loading with ultrasensitive electrochemical biosensing to decode neuronal responses in real time. By mimicking physiologically relevant extension–torsion forces, the system reveals load‐specific biomarker trajectories (T‐Tau, NFL), gene regulation, and apoptosis.
Sultan Khetani, Kar Wey Yong, Mawafag F. Alhasadi, Amir Hamedzadeh, Leila Shahsavari, Atefeh Rafiei, Kalvin Wu, Omakhowa Agbojo, Anupriya Singh, Kunal Karan, Salvatore Federico, Arindom Sen, Amir Sanati‐Nezhad   +12 more
wiley   +1 more source

The relationship between dizziness and sleep: a review of the literature

Frontiers in Neurology
BackgroundThe relation between vestibular disorders and (quality of) sleep is underexplored scientifically and the complex interactions between vestibular and sleep disorders are far from being well understood.
Roeland B. van Leeuwen, Tjard R. Schermer, Tjard R. Schermer, Henri P. Bienfait   +3 more
doaj   +1 more source

Increased risk of vascular events in emergency room patients discharged home with diagnosis of dizziness or vertigo: a 3-year follow-up study. [PDF]

PLoS ONE, 2012
BACKGROUND: Dizziness and vertigo symptoms are commonly seen in emergency room (ER). However, these patients are often discharged without a definite diagnosis.
Ching-Chih Lee, Hsu-Chueh Ho, Yu-Chieh Su, Brian C-H Chiu, Yung-Cheng Su, Yi-Da Lee, Pesus Chou, Sou-Hsin Chien, Yung-Sung Huang   +8 more
doaj   +1 more source