Results 81 to 90 of about 1,710,924 (336)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Handwritten digit recognition: Comparative analysis of ML, CNN, vision transformer, and hybrid models on the MNIST dataset

Journal of Intelligent Systems
Handwritten digit recognition (HDR) remains challenging due to variations in writing styles. To address this challenge, this study comprehensively compares ML (ML) and deep learning (DL) models. We explored a variety of approaches.
Ben Noureddine Dhouha
doaj   +1 more source

Enhancing Disaster Risk Reduction Strategies for Sustainable Tourism Development in Cape Coast, Ghana

Tourism and Hospitality
Cape Coast is a prominent tourism destination in Ghana, distinguished by its historical landmarks, coastal ecosystems, and cultural heritage. Yet the city faces mounting threats from environmental hazards such as coastal erosion, flooding, extreme heat ...
Richmond Yeboah, Mary Acquaye Moore, Emmanuel Dornyoh, Samuel Otoo, Ophelia Mensah   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Deep-Learning-Based ModCod Predictor for Satellite Channels [PDF]

Radioengineering
One of the significant challenges for satellite communications is to serve the ever-increasing demand for the use of finite resources. One option is to increase channel utilization, i.e., to transmit as much data as possible in a given frequency range ...
A. L. Makara, L. Csurgai-Horvath
doaj  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

dl-Alanine Covalently Bonded Giant Arsenotungstate with Rapid Photochromic and Decent Proton Conduction Properties [PDF]

A dl-alanine covalently bonded giant arsenotungstate, namely, Na3Ba11H16[(AsW9O33)6{W2O5(H2O)­(dl-Ala)}2{W3O6(H2O)­(dl-Ala)}2{W2O5(dl-Ala)}] (1; dl-Ala = dl-alanine), has been synthesized and is composed of six [AsW9O33]9– fragments fused together via ...
Bingxue Niu (14236639), Yajing Ye (13884448), Jingyang Niu (1431646), Dongsheng Yang (828941), Jingping Wang (1431640), Kangting Zheng (10833329), Pengtao Ma (779212)   +6 more
core   +1 more source

dl;dl-lacZ [PDF]

, 2017
All lsm files (images taken with a Zeiss 710) of dl;dl-lacZ embryos used in the analysis (quantitative or qualitative) in this paper.
Amy E. Allen (5011622), Stephanie M. Smith (2215477), Smith, Stephanie M., Jacobsen, Thomas, Michael D. O'Connell (5011625), Thomas Jacobsen (749691), Carrell, Sophia N., O'Connell, Michael D., Allen, Amy E., Gregory T Reeves (374988), Sophia N. Carrell (5011628), Reeves, Gregory T   +11 more
core   +1 more source

Circumscription in DL-Lite : progress report [PDF]

, 2023
Circumscription is a prominent approach to bring non-monotonicity to Description Logics (DLs), but unfortunately, it usually displays very high computational complexity of reasoning.
Šimkus, Mantas, Ortiz, Magdalena, Di Stefano, Federica, Bonatti, Piero   +3 more
core   +2 more sources