Results 151 to 160 of about 52,371 (280)
Advanced Science, Volume 13, Issue 57, 14 October 2026.In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao +6 more
wiley +1 more source
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, Volume 13, Issue 57, 14 October 2026.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
American Journal of Hematology, Volume 101, Issue 10, Page 2546-2556, October 2026.ABSTRACT Cardiovascular adverse events (CVAEs) associated with bispecific T‐cell engaging antibodies (BsAbs) have not been systematically investigated across approved agents. In this disproportionality analysis of FAERS (December 2014–September 2025), reports listing BsAbs as the primary suspected drug (n = 7647) were compared with all other drugs in ...
Malak Munir +9 more
wiley +1 more source
Multiple Primary Malignancies Involving Papillary Thyroid Carcinoma: A Three‐Case Series
Clinical Case Reports, Volume 14, Issue 10, October 2026.Patients with papillary thyroid carcinoma may develop distinct additional primary malignancies. New lesions or lymphadenopathy should not be presumed to represent metastatic PTC without tissue confirmation, emphasizing accurate diagnosis, multidisciplinary evaluation, and individualized treatment.
Katayoon Ghasemi +2 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 10, October 2026.ABSTRACT Lymphoma involving the cranial vault is an extremely rare condition that is often difficult to diagnose preoperatively because its imaging findings mimic those of other skull tumors. We report a case of diffuse large B‐cell lymphoma of the cranial vault in a 25‐year‐old man presenting with a rapidly enlarging frontal mass.
Yuki Sakaeyama +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1027-1040, October 2026.Model‐informed drug development is increasingly used to support chimeric antigen receptor (CAR)‐T‐cell therapy programs. However, most population pharmacokinetic (PK) CAR‐T‐cell models available in literature are variations of an empirical piecewise‐linear model, which accurately describes the observed data but lacks a mechanistic foundation.
Anna M. Mc Laughlin +4 more
wiley +1 more source
Excellent Interim Treatment Response with Polatuzumab Vedotin
Turkish Journal of Hematology, 2020 Özgür Mehtap +3 more
doaj +1 more source
HemaSphere, Volume 10, Issue 10, October 2026.Abstract Richter transformation (RT), a highly aggressive lymphoma arising from a preexisting chronic lymphocytic leukemia, represents a major unmet clinical need. Recent data have shown that an antibody–drug conjugate (ADC) targeting the cell‐surface pseudokinase ROR1 is effective in RT patients.
Matilde Micillo +9 more
wiley +1 more source