Results 141 to 150 of about 26,634 (259)

Nanomaterial‐Mediated Radiotherapy–Immunotherapy Combinations: Breaking Immunosuppression and Revolutionizing Cancer Treatment

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Nanomaterials integrate radiotherapy and immunotherapy by enhancing radiosensitivity, remodeling the immunosuppressive tumor microenvironment, and promoting systemic antitumor immunity. This review summarizes the latest strategies of nanomaterial‐mediated combinations (RT, immunotherapy, IRT) and highlights future directions for overcoming clinical ...
Peijie Li, Xiangqin Wang, Sisi He, Hu Ma
wiley   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

MedComm, Volume 7, Issue 9, September 2026.
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu   +5 more
wiley   +1 more source

Use of DLT (blockchain) for international clearing

, 2019
Předmětem této bakalářské práce je identifikace dosavadního vývoje technologie blockchain v rámci mezinárodního clearingu a ohodnoceni dopadu na zajištění platebního styku.
Smirnov, Anton
core   +1 more source

Quantifying Deep Groundwater Contributions to Streamflow With Inequality‐Constrained EEMMA From Sparse Isotope Series in Alpine Permafrost Basins

Earth's Future, Volume 14, Issue 9, September 2026.
Abstract In alpine permafrost basins, dry‐season runoff largely depends on subpermafrost groundwater (BPG, deep groundwater), yet cryohydrogeological conditions are complicated by time‐varying hydrothermal regimes. Combined with the storage and regulation effects of permafrost on runoff, hydrograph‐based estimates of the fractional contribution of BPG ...
Fa Du, Zongxing Li, Juan Gui, James W. Kirchner, Jian Xue, Ahui Zhang   +5 more
wiley   +1 more source

Self‐Organization Shapes Divergent Water Use Strategies of Shrubs for Drought Resilience in Drylands

Water Resources Research, Volume 62, Issue 9, September 2026.
Abstract Differentiation in water use strategies is essential for maintaining the function and resilience of dryland ecosystems. Under prolonged drought, dominant shrubs self‐organize into two typical spatial configurations: scattered with separated individuals and clumped with clustered individuals.
Lei Wang, Guangyao Gao, Ying Ma, Max Rietkerk   +3 more
wiley   +1 more source

The Impact of Enrollment Strategies on the Performance of Time-To-Event Dose-Escalation Designs for Phase I Drug Combination Oncology Trials. [PDF]

Pharm Stat
Tian X, Sweeting M, Broglio K.
europepmc   +1 more source

Characterizing the Forearc Basement and Subducting Structures of the Northern Ecuadorian Margin

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 9, September 2026.
Abstract We present 2D P‐wave velocity (Vp) models from the northern Ecuadorian subduction zone, north of the Carnegie Ridge. Data were collected during the HIPER2 3D wide‐angle seismic experiment, both onshore and offshore. Key seismic profiles were manually picked to determine P‐wave first‐arrival times, which were used for a traveltime tomographic ...
Arnaud Delsuc, Audrey Galve, Mireille Laigle, Andreas Rietbrock, Laure Schenini, Hans Agurto‐Detzel, Alexandra Skrubej, Boris Marcaillou, Sandro Vaca, Annika Maier, Michele Paulatto   +10 more
wiley   +1 more source

Single versus double lung transplantation in patients with pneumoconiosis: a retrospective cohort study. [PDF]

J Occup Med Toxicol
Chen C, Huang Y, Li Z, Wu J, Zhong W, Chen L, Liu F, Qiao G.   +7 more
europepmc   +1 more source

Targeted behavioural and microclimate data collection substantially improves biophysical model predictions of energy expenditure in wild birds

Functional Ecology, Volume 40, Issue 9, Page 2804-2817, September 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Energy is fundamental for life and accurately predicting animals' energy expenditure under changing environments is central to ecology and global change biology. Energy expenditure in free‐living animals can be directly quantified using the doubly labelled water (DLW ...
Shannon R. Conradie, Amanda R. Bourne, Ryno Kemp, Barry van Jaarsveld, Zenon J. Czenze, Amanda R. Ridley, Andrew E. McKechnie, Susan J. Cunningham   +7 more
wiley   +1 more source