Results 151 to 160 of about 60,875 (277)

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

Circulatory CCL2 distinguishes Duchenne muscular dystrophy dogs

Disease Models & Mechanisms
Dennis O. Pérez-López, Matthew J. Burke, Chady H. Hakim, James A. Teixeira, Jin Han, Yongping Yue, Zewei Ren, Jianguo Sun, Shi-jie Chen, Roland W. Herzog, Gang Yao, Dongsheng Duan   +11 more
doaj   +1 more source

MicroRNA-mRNA Networks in Skeletal Muscle of Tailored Pig Models for Dystrophinopathies. [PDF]

J Cachexia Sarcopenia Muscle
Reschke S, Graf A, Hadlich F, Jaudas F, Fröhlich T, Stirm M, Klymiuk N, Krebs S, Wolf E, Ali A.   +9 more
europepmc   +1 more source

Fetal Cells in Maternal Blood for Noninvasive Prenatal Testing—Is it Still a Distant Star?

Prenatal Diagnosis, EarlyView.
ABSTRACT Accurate and safe prenatal diagnosis of severe genetic disorders remains challenging despite advances in genomic technologies and increased use of cell‐free noninvasive prenatal testing (cfNIPT). Currently, approximately half of pathogenic copy number variants (pCNVs) and most monogenic disorders are identified only postnatally.
Ripudaman Singh, Katarina Ravn, Line Dahl Jeppesen, Maria Bach Laursen, Maibritt Nøgaard Lauridsen, Mathias Kølvraa, Marlene Christina Nielsen, Bolette Hestbek Nicolaisen, Inga Baach Cristensen, Morten Muhlig Nielsen, Britt Kidmose Ardal, Lars Henning Pedersen, Mads Tang Dalsgaard, Ida Vogel, Lotte Hatt   +14 more
wiley   +1 more source

Spectral Submanifolds of Delay Systems: Control in Continuous and Discrete Time

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT This paper presents both continuous‐time and discretization‐based approaches for constructing spectral submanifolds (SSMs) for time delay systems. The continuous‐time approach built upon sun–star calculus, reformulates the governing delay differential equation (DDE) as an operator differential equation (OpDE).
Bence Szaksz, Gábor Orosz, Gábor Stépán   +2 more
wiley   +1 more source

DWORF expression is reduced in a large animal model of Duchenne muscular dystrophy

Disease Models & Mechanisms
Aaron M. Gibson, Xiufang Pan, Omar Brito-Estrada, James A. Teixeira, Lauren K. Carl, Yongping Yue, Michael L. Kamradt, Matthew J. Burke, Caris A. Wadding-Lee, Gang Yao, Roland W. Herzog, Dongsheng Duan, Catherine A. Makarewich   +12 more
doaj   +1 more source

Genetic Analysis and Reproductive Intervention in a Duchenne Muscular Dystrophy Family With Cryptic Complex Chromosomal Rearrangement Identified by Structural Variation Sequencing. [PDF]

Hum Mutat
Qin S, Wang X, Wang J, Leng X, Zhang Z, Chen X, Yin Y.   +6 more
europepmc   +1 more source

DMD & BMD – CLINICAL: P.51 DMD Hub: demonstrating impact for DMD trials

, 2020
Heslop, E., Guglieri, M., Irvin, A., Turner, C., Crow, B., George, E., Johnson, A., Crossley, E., Muntoni, F., Straub, V.   +9 more
openaire   +1 more source

Ecohydrology‐Informed Machine Learning for Floodplain Vegetation Classification to Support Riverine Nature‐Based Solutions

Remote Sensing in Ecology and Conservation, EarlyView.
Ecohydrological theory was used to inform supervised machine learning algorithms through a novel multidisciplinary data fusion approach for vegetation and habitat classification in a large river floodplain, an ecosystem of high biodiversity, landcover heterogeneity, and conservation importance.
Rabindra Parajuli, Matthew L. Chambers, Deepak R. Mishra, Aidan E. Coen, Kevin Samples, David J. Crane, Mark D. Dixon, Charles B. van Rees   +7 more
wiley   +1 more source

Why wolves walk – drivers of daily movement in a social large carnivore

Wildlife Biology, EarlyView.
Animal movement patterns are influenced by a range of extrinsic and intrinsic factors, including the distribution of resources, human disturbance, landscape connectivity, species interactions, and individual traits. We examined factors associated with daily movement distance (DMD) and linearity in 20 territorial Scandinavian wolves Canis lupus during ...
Julia Björk, Håkan Sand, Petter Wabakken, Barbara Zimmermann, Camilla Wikenros   +4 more
wiley   +1 more source