Results 51 to 60 of about 13,815,827 (291)

A Trajectory Optimisation-Based Incremental Learning Strategy for Learning from Demonstration

Applied Sciences
The insufficient generalisation capability of the conventional learning from demonstration (LfD) model necessitates redemonstrations. In addition, retraining the model can overwrite existing knowledge, making it impossible to perform previously acquired ...
Yuqi Wang, Weidong Li, Yuchen Liang
doaj   +1 more source

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Differential Morphological Profile Neural Networks for Semantic Segmentation

Remote Sensing
Semantic segmentation of overhead remote sensing imagery supports critical applications in mapping, urban planning, and disaster response, yet state-of-the-art segmentation networks are predominantly designed for ground-perspective imagery and do not ...
David Huangal, J. Alex Hurt
doaj   +1 more source

Local and Systemic Delivery of the BimS Gene Nano-Complex for Efficient Oral Squamous Cell Carcinoma Therapy

International Journal of Nanomedicine, 2022
Pingchuan Ma,1 Jingmei Li,2 Yan Gao,2 Jieping Wu,2 Ke Men,2 Chunjie Li,1 Yi Men,1 Xingmei Duan3 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of ...
Ma P, Li J, Gao Y, Wu J, Men K, Li C, Men Y, Duan X   +7 more
doaj  

Study on the rapid measurement of carbon content in marine sediments based on the model transfer of hyperspectral imaging camera and spectrometer

Results in Chemistry, 2023
Laboratory spectrometer and hyperspectral imaging camera are two instruments for obtaining spectral information of substances. Both instruments have advantages in practical applications.
Wang Zijian, Jia Zongchao, Li Xueying, Qiu Huimin, Hou Guangli, Fan Pingping   +5 more
doaj   +1 more source

DNA methylome and transcriptome analysis established a model of four differentially methylated positions (DMPs) as a diagnostic marker in esophageal adenocarcinoma early detection

PeerJ, 2021
Background Esophageal carcinogenesis involves in alterations of DNA methylation and gene transcription. This study profiled genomic DNA methylome vs. gene expression using transcriptome data on esophageal adenocarcinoma (EAC) tissues from the online databases in order to identify methylation biomarkers in EAC ...
Weilin Peng, Guangxu Tu, Zhenyu Zhao, Boxue He, Qidong Cai, Pengfei Zhang, Xiong Peng, Shuai Shi, Xiang Wang   +8 more
openaire   +3 more sources

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Decouple H2O2 Electrosynthesis From Microenvironmental Decomposition via Atomic Site Density Engineering

Angewandte Chemie, EarlyView.
Using defect‐rich Co‐N2O2 single‐atom catalysts as a model system, this work reveals that atomic site density governs the competition between H2O2 electrosynthesis and microenvironmental decomposition during 2e−‐ORR. Optimised site isolation suppresses HPRR and HDR, thereby establishing a site‐density principle to balance H2O2 formation and ...
Junwen Chen, Hongyu Zhou, Qiming Zhang, Shuang Zhong, Wei Ren, Lei Shi, Li Gao, Shaobin Wang, Xiaoguang Duan   +8 more
wiley   +2 more sources

In-depth exploration of 2,5-dimethylpyrazine in traditional charcoal-grilled lamb: a study using food and model reaction systems and density functional theory

Food Science of Animal Products
Charcoal-grilled food is favored for its strong roasted and nutty aroma, and grilled lamb’s flavor characteristics are significantly affected by compounds such as 2,5-dimethylpyrazine (2,5-DMP). This study explored the formation and reactivity of 2,5-DMP
Yuan Wang, Hui Yang, Huan Liu, Kexin Cheng, Huiqi Yan, Kexin Li, Runmi Tao, Guoqing Ye, Shengmei Gai, Dengyong Liu   +9 more
doaj   +1 more source

Inactivation of PI3K/Akt promotes the odontoblastic differentiation and suppresses the stemness with autophagic flux in dental pulp cells

Journal of Dental Sciences, 2022
Background/purpose: Autophagy is involved in controlling differentiation of various cell types. The present study aimed to investigate the mechanism related to autophagy in regulating odontogenic differentiation of dental pulp cells.
Sam Young Park, Heui Seung Cho, Kyung Hwun Chung, Bin Na Lee, Sun Hun Kim, Won Jae Kim, Ji Yeon Jung   +6 more
doaj   +1 more source