Results 201 to 210 of about 254,372 (361)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Absence of Testes at Puberty Impacts Functional Development of Nigrostriatal But Not Mesoaccumbal Dopamine Terminals in a Wild-Derived Mouse. [PDF]

eNeuro
Jackson S, Mun J, Prounis G, Phumsatitpong C, Motahari N, Kriegsfeld L, Landry MP, Wilbrecht L.   +7 more
europepmc   +1 more source

Simulating the Fate of Dimethyl Sulfide (DMS) in the Atmosphere: A Review of Emission and Chemical Parameterizations [PDF]

Ernesto Pino‐Cortés, Mariela Martínez, Katherine Gómez, Fernando González Taboada, Joshua S. Fu, Golam Sarwar, Rafael P. Fernández, Sankirna D. Joge, Anoop S. Mahajan, Juan Höfer   +9 more
openalex   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

AbAgym: a well-curated dataset for the mutational analysis of antibody-antigen complexes. [PDF]

MAbs
Cia G, Li D, Poblete S, Rooman M, Pucci F.   +4 more
europepmc   +1 more source

Slide into our DMs [PDF]

, 2018
Rubin, Jami
core  

DMS sea-to-air fluxes and their influence on sulfate aerosols over the Southern Ocean, south-east Indian Ocean and north-west Pacific Ocean

, 2021
Miming Zhang, Christa Marandino, Jinpei Yan, Qi Lin, Keyhong Park, Guojie Xu   +5 more
openalex   +2 more sources

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Foundational Report Series: Advanced Distribution Management Systems for Grid Modernization, Business Case Calculations for DMS

, 2017
Xiaonan Lu, Ravindra Singh, Jianhui Wang, James Reilly   +3 more
openalex   +2 more sources

Concentrations and cycling of DMS, DMSP, and DMSO in coastal and offshore waters of the Subarctic Pacific during summer, 2010‐2011

, 2017
E. Asher, J. Dacey, D. Ianson, A. Peña, P. Tortell   +4 more
semanticscholar   +1 more source