Results 51 to 60 of about 60,289 (232)

Rings in the Extreme: PCNA Interactions and Adaptations in the Archaea [PDF]

, 2012
Biochemical and structural analysis of archaeal proteins has enabled us to gain great insight into many eukaryotic processes, simultaneously offering fascinating glimpses into the adaptation and evolution of proteins at the extremes of life. The archaeal
Bunting, KA, Winter, JA
core   +2 more sources

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors

Biology Direct, 2009
Background Evolution of DNA polymerases, the key enzymes of DNA replication and repair, is central to any reconstruction of the history of cellular life.
Pavlov Youri I, Rogozin Igor B, Makarova Kira S, Tahirov Tahir H, Koonin Eugene V   +4 more
doaj   +1 more source

Do Archaea and bacteria co-infection have a role in the pathogenesis of chronic chagasic cardiopathy?

Memorias do Instituto Oswaldo Cruz, 2009
Chronic cardiopathy (CC) in Chagas disease is a fibrotic myocarditis with C5b-9 complement deposition. Mycoplasma and Chlamydia may interfere with the complement response.
Maria de Lourdes Higuchi, Joyce Kawakami, Renata Ikegami, Maysa Beatriz Mandetta Clementino, Flavio M Kawamoto, Marcia M Reis, Edimar Bocchi   +6 more
doaj   +1 more source

Simultaneous amplicon sequencing to explore co-occurrence patterns of bacterial, archaeal and eukaryotic microorganisms in rumen microbial communities. [PDF]

PLoS ONE, 2013
Ruminants rely on a complex rumen microbial community to convert dietary plant material to energy-yielding products. Here we developed a method to simultaneously analyze the community's bacterial and archaeal 16S rRNA genes, ciliate 18S rRNA genes and ...
Sandra Kittelmann, Henning Seedorf, William A Walters, Jose C Clemente, Rob Knight, Jeffrey I Gordon, Peter H Janssen   +6 more
doaj   +1 more source

Cas1 and Fen1 Display Equivalent Functions During Archaeal DNA Repair

Frontiers in Microbiology, 2022
CRISPR-Cas constitutes an adaptive prokaryotic defence system against invasive nucleic acids like viruses and plasmids. Beyond their role in immunity, CRISPR-Cas systems have been shown to closely interact with components of cellular DNA repair pathways,
Julia Wörtz, Victoria Smith, Jörg Fallmann, Sabine König, Sabine König, Tharani Thuraisingam, Paul Walther, Henning Urlaub, Henning Urlaub, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Thorsten Allers, Frank Hille, Anita Marchfelder   +19 more
doaj   +1 more source

TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle [PDF]

, 2016
Transcription is an intrinsically dynamic process and requires the coordinated interplay of RNA polymerases (RNAPs) with nucleic acids and transcription factors.
Gietl, Andreas, Grohmann, Dina, Schulz, Sarah, Smollett, Katherine, Tinnefeld, Philip, Werner, Finn   +5 more
core   +1 more source

Processing of DNA lesions by archaeal DNA polymerases from Sulfolobus solfataricus [PDF]

Nucleic Acids Research, 2003
Spontaneous damage to DNA as a result of deamination, oxidation and depurination is greatly accelerated at high temperatures. Hyperthermophilic microorganisms constantly exposed to temperatures exceeding 80 degrees C are endowed with powerful DNA repair mechanisms to maintain genome stability.
Gruz P, Shimizu M, Pisani F M, De Felice M, Kanke Y, Nohmi T   +5 more
openaire   +4 more sources

Processing of matched and mismatched rNMPs in DNA by archaeal ribonucleotide excision repair

iScience, 2023
Summary: Ribonucleoside monophosphates (rNMPs) are the main non-canonical nucleotides in genomic DNA, and their incorporation can occur as mismatches or matches in vivo.
Maurane Reveil, Lucie Chapel, Blandine Vourc’h, Audrey Bossé, Léa Vialle, Raphaël Brizard, Yann Moalic, Mohamed Jebbar, Ghislaine Henneke   +8 more
doaj   +1 more source

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [PDF]

, 2013
In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA.
A Costa, A Fernández-Cid, Alberto Riera, Alejandra Fernández-Cid, AS Brewster, AY Lyubimov, B Stillman, BA Kelch, BI Khayrutdinov, Bruce Stillman, C Evrin, C Evrin, C Liu, C Santocanale, C Speck, C Speck, Cecile Evrin, Christian Speck, D Remus, D Remus, D Suck, E Arias-Palomo, EF Pettersen, EL Dueber, G Tang, GC Lander, GD Bowman, GD Pintilie, H Li, H Li, Hironori Kawakami, Huilin Li, I Ilves, IN Chesnokov, J Frigola, J Liu, J Sun, JC Randell, Jingchuan Sun, JL Bowers, L Zou, M Gaudier, M O'Donnell, MG Clarey, MG Clarey, ML Baker, ML Bochman, ML Bochman, ML Bochman, PW Lau, R Henderson, RC Heller, RD Klemm, RJ Fletcher, S Chen, S Donovan, S Onesti, S Waga, SE Moyer, SL Forsburg, SP Bell, SP Bell, Stefan A Samel, T Miyata, T Pape, Y Ishimi, Y Kawasaki, YH Kang, Z Chen   +68 more
core   +1 more source

Archaeal DNA polymerases: new frontiers in DNA replication and repair [PDF]

Emerging Topics in Life Sciences, 2018
Archaeal DNA polymerases have long been studied due to their superior properties for DNA amplification in the polymerase chain reaction and DNA sequencing technologies. However, a full comprehension of their functions, recruitment and regulation as part of the replisome during genome replication and DNA repair lags behind well-established bacterial and
openaire   +2 more sources