Results 71 to 80 of about 60,289 (232)

The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation [PDF]

, 2009
Background: The high intracellular salt concentration re quired to maintain a halophilic lifestyle poses challenges to haloarchaeal proteins that must stay soluble, stable and functional in this extreme environment.
Bunting, KA, Christofi, P, Morroll, S, Winter, JA   +3 more
core   +2 more sources

Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification

iMetaOmics, EarlyView.
We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N‐terminal regions, repeat sequences, and sequences motifs. We developed an AI‐driven algorithm, Cas12fam, which allows precise annotation of 18 distinct domains in Cas12 proteins.
Meixia Yu, Zilong Zhao, Peiyang Li, Yunpeng Teng, Feng Xu, Zhimeng Li, Zhijia Yang, Hainan Zhao, Huanbin Zhou, Lanqin Xia, Jinsheng Lai, Beibei Xin   +11 more
wiley   +1 more source

Metagenome datasets from women with polycystic ovary syndrome from Irkutsk, Eastern Siberia, Russia

Data in Brief, 2020
For the metagenomic characterization of potential taxonomic and functional diversity of microorganisms associated with polycystic ovary syndrome (PCOS) in women, we surveyed five women with PCOS and collected samples of feces, saliva, and serum.
Natalia Belkova, Elizaveta Klimenko, Naliia Vilson, Alexsandra Sambialova, Daria Markova, Ilia Igumnov, Larisa Suturina   +6 more
doaj   +1 more source

Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba [PDF]

, 2013
Archaea use a variety of small basic proteins to package their DNA. One of the most widespread and highly conserved is the Alba (Sso10b) protein. Alba interacts with both DNA and RNA in vitro, and we show in the present study that it binds more tightly ...
Ingledew, W John, Jelinska, Clare, Petrovic-Stojanovska, Biljana, White, Malcolm F   +3 more
core   +1 more source

Inhibition of translesion DNA polymerase by archaeal reverse gyrase [PDF]

Nucleic Acids Research, 2009
Reverse gyrase is a unique DNA topoisomerase endowed with ATP-dependent positive supercoiling activity. It is typical of microorganisms living at high temperature and might play a role in maintenance of genome stability and repair. We have identified the translesion DNA polymerase SsoPolY/Dpo4 as one partner of reverse gyrase in the hyperthermophilic ...
Valenti A, Perugino G, Nohmi T, Rossi M, Ciaramella M   +4 more
openaire   +5 more sources

Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries

iMetaOmics, EarlyView.
Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo, Xiyang Dong, Jia‑Ling Li, Ji‐Cheng Yao, Ziqi Peng, Qi Li, Zi‐Wen Yang, Yang Yuan, Wen‑Jun Li, Pandeng Wang   +9 more
wiley   +1 more source

The role of the gut microbiome in the regulation of high‐altitude adaptation

iMeta, EarlyView.
This study is the first to elucidate mechanisms of high‐altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude since birth as comparative models. Through a systematic comparison of their rumen ecology using multi‐omics approaches—including rumen metagenomics ...
Xinyu Zhang, Senlin Zhu, Michael Kreuzer, Shoukun Ji, Wei Wang, Yanliang Bi, Shengli Li   +6 more
wiley   +1 more source

The Sulfolobus solfataricus radA paralogue sso0777 is DNA damage inducible and positively regulated by the Sta1 protein [PDF]

, 2007
Little is known about the regulation of the DNA damage-mediated gene expression in archaea. Here we report that the addition of actinomycin D to Sulfolobus solfataricus cultures triggers the expression of the radA paralogue sso0777.
Abella, M, Barbe, J, Campoy, S, Paytubi, S, Rodriquez, S, White, Malcolm Frederick   +5 more
core   +1 more source

Archaeal Minichromosome Maintenance (MCM) Helicase Can Unwind DNA Bound by Archaeal Histones and Transcription Factors [PDF]

Journal of Biological Chemistry, 2007
Protein-DNA complexes must be disassembled to facilitate DNA replication. Replication forks contain a helicase that unwinds the duplex DNA at the front of the fork. The minichromosome maintenance helicase from the archaeon Methanothermobacter thermautotrophicus required only ATP to unwind DNA bound into complexes by the M.
Jae-Ho, Shin, Thomas J, Santangelo, Yunwei, Xie, John N, Reeve, Zvi, Kelman   +4 more
openaire   +2 more sources

Majorbio Cloud 2026 provides comprehensive analysis workflows for microbiome

iMeta, EarlyView.
The integrated microbiome data analysis platform on Majorbio Cloud (https://cloud.majorbio.com/) encompasses 26 analytical workflows, with a core architecture of two modules: single‐omics workflows and cross‐omics integration and correlation workflows.
Jianhua Zhao, Linmeng Liu, Jichen Han, Junbiao Zhang, Xiaodan Li, Yan Wang, Qianhui Han, Xue Gong, Linna Zhang, Hao Gao, Bing Yang, Yachen Dong, Huasheng Huang, Xianglin Zhang, Kegang Yu   +14 more
wiley   +1 more source