Results 181 to 190 of about 805,503 (267)

Epigenetic Reprogramming by <i>Mycobacterium tuberculosis</i> Secretory Proteins: Implications for Pathogenesis and Therapy. [PDF]

Antibiotics (Basel)
Rv K, Asif N, Sethunath AN, Thekkumkara DT, Binu D, Krishna G, Sureshkumar AA, Menon AM, Thomas SS, Abhinand K, Sasikumar A, Padmakumar S, Paniker A, Babu P, Kumar GB, Nair BG, Madhavan A.   +16 more
europepmc   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Innate immune recognition and immunomodulatory effects of bacteriophages: implications for phage therapy. [PDF]

Front Immunol
Hanawa T, Tanaka M, Nagano DS, Shirato K, Hasegawa-Ishii S, Matsuda T.   +5 more
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Phyllosphere microbiome responses to spray-induced gene silencing targeting Phytophthora infestans in potato. [PDF]

NPJ Biofilms Microbiomes
Ghosh S, Sundararajan P, Gelena Kelbessa B, Ghadamgahi F, Whisson SC, Dubey M, Chawade A, Vetukuri RR.   +7 more
europepmc   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Pathogenesis and genome characterization of translucent post-larvae disease-causing <i>Vibrio parahaemolyticus</i> in <i>Litopenaeus vannamei</i>. [PDF]

Curr Res Microb Sci
Kumar R, Azzahidah A, Teoh YH, Lin SJ, Dhar AK, Lin SS, Wang HC, Lo CF, Wang HC.   +8 more
europepmc   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Searching for vertically transmitted endosymbionts in over 4,000 wild strains of three self-fertilizing <i>Caenorhabditis</i> species. [PDF]

MicroPubl Biol
O'Connor LM, Singh A, Luallen RJ, Zhang G, Andersen EC.   +4 more
europepmc   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source