Results 131 to 140 of about 2,253,680 (310)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Torsional Mechanics of Circular DNA
Circular DNA found in the cell is actively regulated to an underwound state, with their superhelical density close to σ ∼ - 0.06. While this underwound state is essential to life, how it impacts the torsional mechanical properties of DNA is not fully understood.
Gundeep Singh +4 more
openaire +2 more sources
Síntese de polietilenoiminas ramificadas decoradas com grupos hidrofóbicos e nucleosídeos e estudos de sua interação com dodecilsulfato de sódio e DNA [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciencias Fisicas e Matematicas, Programa de Pós-Graduação em Química, Florianópolis, 2012A poli(etilenoimina) (PEI) foi modificada por meio da alquilação com grupos n-alquila (n = 4, 6,
Bellettini, Ismael Casagrande
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, 2021 In accordance with the State Corporations Act, Cap. 446, Sections 11 and 12 and the Public Finance Management Act, 2012 (PFMA), Section 68, All State Corporations are required to prepare and submit their proposed budgets to the Parent Ministry and the ...
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The extrachromosomal circular DNA atlas of aged and young mouse brains
Scientific DataExtrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation ...
Xiaoning Hong +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Circular on Mandatory In-Service Training Programmes in The Public Service [PDF]
The Public Service Commission vide a circular Ref.No. PSC/ ADM/13 ( 6) of 11.3.2020 suspended the requirements of Strategic Leadership Development Programmes (SLDP) and Masters Degree as parameters for promotion of public officers to senior positions ...
The Public Service Commission
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
This is the first ever doctoral thesis in the field of DNA computation. The field has its roots in the late 1950s, when the Nobel laureate Richard Feynman first introduced the concept of computing at a molecular level. Feynman's visionary idea was only
Amos, Martyn
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