Results 31 to 40 of about 428,487 (304)

New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation

Cells, 2020
The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease ...
Alexander L. Marchetti, Haitao Guo
doaj   +1 more source

Condensation of circular DNA [PDF]

The Journal of Chemical Physics, 2013
A simple model of a circularly closed double-stranded DNA in a poor solvent is considered as an example of a semi-flexible polymer with self-attraction. To find the ground states, the conformational energy is computed as a sum of the bending and torsional elastic components and the effective self-attraction energy.
openaire   +3 more sources

Dataset on the effects of spermidine on linking number differences between histone H1-free and histone H1-bound circular polynucleosomes

Data in Brief, 2018
The data presented in this article are related to the research article entitled ''Quantitative determination of linking number differences between circular polynucleosomes and histone H1-bound circular polynucleosomes'' Zhang et al. (in press) [1].
Hao Zhang, Tianhu Li
doaj   +1 more source

Sensitive detection of circular DNAs at single-nucleotide resolution using guided realignment of partially aligned reads

BMC Bioinformatics, 2019
Background Circular DNA has recently been identified across different species including human normal and cancerous tissue, but short-read mappers are unable to align many of the reads crossing circle junctions hence limiting their detection from short ...
Iñigo Prada-Luengo, Anders Krogh, Lasse Maretty, Birgitte Regenberg   +3 more
doaj   +1 more source

HBV COVALENTLY CLOSED CIRCULAR DNA AS A MARKER OF PREVALENCE OF OCCULT HEPATITIS В IN PATIENTS WITH HBV, HDV AND HCV INFECTION IN UZBEKISTAN

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Aim. Evaluate significance of covalently closed circular DNA of hepatitis В virus as a marker for detection of occult viral hepatitis В in Uzbekistan population with hepatitis of various genesis. Materials and methods.
A. V. Semenov, Yu. V. Ostankova, Kh. N. Faizullaev, E. I. Kazakova, A. V. Kozlov, E. I. Musabaev, A. A. Totolyan   +6 more
doaj   +1 more source

Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD [PDF]

, 2013
The helicase PcrA unwinds DNA during asymmetric replication of plasmids, acting with an initiator protein, in our case RepD. Detailed kinetics of PcrA activity were measured using bulk solution and a single-molecule imaging technique to investigate the ...
Arbore, Arthur, Atkinson, Bird, Brune, Byrd, Byrd, Chao, Cheng, Christopher P. Toseland, Corrie, Dillingham, Dillingham, Dillingham, Dillingham, Dillingham, Fili, Fili, Gorbalenya, Greenstein, Gregory I. Mashanov, Iordanescu, Justin E. Molloy, Kunzelmann, Leatherbarrow, Lee, Levin, Liisa T. Chisty, Lohman, Lohman, Manosas, Mark S. Dillingham, Martin R. Webb, Mashanov, Natalia Fili, Niedziela-Majka, Noirot, Sellers, Singleton, Slatter, Soultanas, Soultanas, Soultanas, Subramanya, Thomas, Thomas, Toseland, Veaute, Velankar, Webb, Yamaguchi, Yang, Yarranton, Yeeles, Zhang   +54 more
core   +1 more source

The Knot Spectrum of Confined Random Equilateral Polygons

Computational and Mathematical Biophysics, 2014
It is well known that genomic materials (long DNA chains) of living organisms are often packed compactly under extreme confining conditions using macromolecular self-assembly processes but the general DNA packing mechanism remains an unsolved problem. It
Diao Y., Ernst C., Montemayor A., Rawdon E., Ziegler U.   +4 more
doaj   +1 more source

DNA Binding in High Salt: Analysing the Salt Dependence of Replication Protein A3 from the Halophile Haloferax volcanii [PDF]

, 2012
Halophilic archaea maintain intracellular salt concentrations close to saturation to survive in high-salt environments and their cellular processes have adapted to function under these conditions.
Bunting, KA, Patoli, B, Winter, JA
core   +2 more sources

Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor.

PLoS ONE, 2019
Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and ...
Fumihiko Takeuchi, Sotaro Ikeda, Yuta Tsukamoto, Yoshikazu Iwasawa, Chen Qihao, Yukie Otakaki, Ouda Ryota, Wan-Ling Yao, Ryo Narita, Hijikata Makoto, Koichi Watashi, Takaji Wakita, Koh Takeuchi, Kazuaki Chayama, Amane Kogure, Hiroki Kato, Takashi Fujita   +16 more
doaj   +1 more source

A localized transition in the size variation of circular DNA in nanofluidic slitlike confinement

AIP Advances, 2013
We report strong evidence for a localized transition in the size variation of circular DNA between strong and moderate regimes of slitlike confinement. A novel and rigorous statistical analysis was applied to our recent experimental measurements of DNA ...
Elizabeth A. Strychalski, Samuel M. Stavis, Jon Geist   +2 more
doaj   +1 more source