Results 31 to 40 of about 2,877,234 (303)

Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae

bioRxiv, 2020
Circular DNA of chromosomal origin form from all parts of eukaryotic genomes. In yeast, circular rDNA accumulates as cells divide, contributing to replicative aging.
Iñigo Prada-Luengo, Henrik D. Møller, R. Henriksen, Qian Gao, C. E. Larsen, Sefa Alizadeh, L. Maretty, J. Houseley, Birgitte Regenberg   +8 more
semanticscholar   +1 more source

Small Circular DNA Molecules as Triangular Scaffolds for the Growth of 3D Single Crystals

Biomolecules, 2020
DNA is a very useful molecule for the programmed self-assembly of 3D (three dimension) nanoscale structures. The organised 3D DNA assemblies and crystals enable scientists to conduct studies for many applications such as enzymatic catalysis, biological ...
Yu Wang, Xin Guo, Bo Kou, Ling Zhang, Shou-Jun Xiao   +4 more
doaj   +1 more source

Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration

International Journal of Molecular Sciences, 2020
Still unresolved is the question of how a lifetime accumulation of somatic gene copy number alterations impact organ functionality and aging and age-related pathologies.
Quratul Ain, C. Schmeer, Diane Wengerodt, O. Witte, A. Kretz   +4 more
semanticscholar   +1 more source

The adaptive potential of circular DNA accumulation in ageing cells

Current Genetics, 2020
Carefully maintained and precisely inherited chromosomal DNA provides long-term genetic stability, but eukaryotic cells facing environmental challenges can benefit from the accumulation of less stable DNA species.
R. Hull, J. Houseley
semanticscholar   +1 more source

New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation

Cells, 2020
The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease ...
Alexander L. Marchetti, Haitao Guo
doaj   +1 more source

Condensation of circular DNA [PDF]

The Journal of Chemical Physics, 2013
A simple model of a circularly closed double-stranded DNA in a poor solvent is considered as an example of a semi-flexible polymer with self-attraction. To find the ground states, the conformational energy is computed as a sum of the bending and torsional elastic components and the effective self-attraction energy.
openaire   +3 more sources

Discovery of several thousand highly diverse circular DNA viruses

bioRxiv, 2019
Although it is suspected that there are millions of distinct viral species, fewer than 9,000 are catalogued in GenBank’s RefSeq database. We selectively enriched for and amplified the genomes of circular DNA viruses in over 70 animal samples, ranging ...
M. Tisza, D. Pastrana, N. Welch, Brittany N. Stewart, A. Peretti, G. Starrett, Y. Y. Pang, S. Krishnamurthy, P. Pesavento, David H. McDermott, P. Murphy, Jessica L. Whited, Bess M. Miller, J. Brenchley, Stephan P. Rosshart, B. Rehermann, J. Doorbar, Blake A. Ta’ala, O. Pletnikova, J. Troncoso, S. Resnick, B. Bolduc, M. Sullivan, A. Varsani, A. Segall, C. Buck   +25 more
semanticscholar   +1 more source

Dataset on the effects of spermidine on linking number differences between histone H1-free and histone H1-bound circular polynucleosomes

Data in Brief, 2018
The data presented in this article are related to the research article entitled ''Quantitative determination of linking number differences between circular polynucleosomes and histone H1-bound circular polynucleosomes'' Zhang et al. (in press) [1].
Hao Zhang, Tianhu Li
doaj   +1 more source

Topological barrier to Cas12a activation by circular DNA nanostructures facilitates autocatalysis and transforms DNA/RNA sensing

Nature Communications
Control of CRISPR/Cas12a trans-cleavage is crucial for biosensor development. Here, we show that small circular DNA nanostructures which partially match guide RNA sequences only minimally activate Cas12a ribonucleoproteins.
Fei Deng, Yi Li, Biyao Yang, Rui Sang, Wei Deng, Maya Kansara, Frank Lin, S. Thavaneswaran, David M. Thomas, Ewa M. Goldys   +9 more
semanticscholar   +1 more source

A localized transition in the size variation of circular DNA in nanofluidic slitlike confinement

AIP Advances, 2013
We report strong evidence for a localized transition in the size variation of circular DNA between strong and moderate regimes of slitlike confinement. A novel and rigorous statistical analysis was applied to our recent experimental measurements of DNA ...
Elizabeth A. Strychalski, Samuel M. Stavis, Jon Geist   +2 more
doaj   +1 more source