Simulations of Knotting in Confined Circular DNA [PDF]
Biophysical Journal, 2008 The packing of DNA inside bacteriophages arguably yields the simplest example of genome organization in living organisms. As an assay of packing geometry, the DNA knot spectrum produced upon release of viral DNA from the P4 phage capsid has been analyzed, and compared to results of simulation of knots in confined volumes.
Micheletti, Cristian +3 more
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Electron microscopic observation of mitochondrial DNA isolated from a human kidney: circular dimers in histologically normal organ mitochondria [PDF]
, 1971 Circular DNA isolated from human kidney mitochondria was studied by electron microscopy. I. Mean contour length of monomers of the mitochondrial DNA was 4.96 ± SE 0.28 /μ 2.
Hirata, Seiichi +2 more
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New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation
Cells, 2020 The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease ...
Alexander L. Marchetti, Haitao Guo
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Circular binary segmentation for the analysis of array-based DNA copy number data.
Biostatistics, 2004 DNA sequence copy number is the number of copies of DNA at a region of a genome. Cancer progression often involves alterations in DNA copy number. Newly developed microarray technologies enable simultaneous measurement of copy number at thousands of ...
A. Olshen +3 more
semanticscholar +1 more source
Denaturation of circular DNA: Supercoils and overtwist [PDF]
Physical Review E, 2012 The denaturation transition of circular DNA is studied within a Poland-Scheraga type approach, generalized to account for the fact that the total linking number (LK), which measures the number of windings of one strand around the other, is conserved. In the model the LK conservation is maintained by invoking both overtwisting and writhing (supercoiling)
Bar, Amir +2 more
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Circular DNA elements of chromosomal origin are common in healthy human somatic tissue
Nature Communications, 2018 The human genome is generally organized into stable chromosomes, and only tumor cells are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements (eccDNAs).
Henrik D. Møller +11 more
semanticscholar +1 more source
Transposable elements and circular DNAs [PDF]
Mobile Genetic Elements, 2016 Circular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs).
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Discovery of several thousand highly diverse circular DNA viruses
bioRxiv, 2019 Although it is suspected that there are millions of distinct viral species, fewer than 9,000 are catalogued in GenBank’s RefSeq database. We selectively enriched for and amplified the genomes of circular DNA viruses in over 70 animal samples, ranging ...
Michael J. Tisza +25 more
semanticscholar +1 more source
Synthetic metallomolecules as agents for the control of DNA structure [PDF]
, 2007 This tutorial review summarises B-DNA structure and metallomolecule binding modes and illustrates some DNA structures induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt amines, ruthenium octahedral metal complexes,
Adair D. Richards +54 more
core +1 more source
A localized transition in the size variation of circular DNA in nanofluidic slitlike confinement
AIP Advances, 2013 We report strong evidence for a localized transition in the size variation of circular DNA between strong and moderate regimes of slitlike confinement. A novel and rigorous statistical analysis was applied to our recent experimental measurements of DNA ...
Elizabeth A. Strychalski +2 more
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