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Mitochondrial DNA of Kinetoplastids
1992Publisher Summary This chapter highlights mitochondrial DNA of kinetoplastids. Kinetoplast DNA (kDNA) is the unusual mitochondrial DNA characteristic of members of Kinetoplastida. This DNA has two distinctive general features—namely, (1) it comprises two classes of unrelated circular molecules, maxicircles and minicircles, and (2) in each cell these ...
Kenneth Stuart, Jean E. Feagin
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DUPLICATIONS OF MITOCHONDRIAL DNA IN MITOCHONDRIAL MYOPATHY
The Lancet, 1989Restriction enzyme analysis was done on total cellular DNA extracted from whole blood in two patients with mitochondrial myopathy and multisystem involvement and their families. The two patients had an abnormal mitochondrial genome with a large (about 8 kb) duplication present in several tissues.
R. Mark Gardiner +2 more
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Maintenance and Expression of Mammalian Mitochondrial DNA.
Annual Review of Biochemistry, 2016Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the function of the oxidative phosphorylation system, which is composed of four respiratory-chain complexes and adenosine triphosphate (ATP) synthase.
C. Gustafsson, M. Falkenberg, N. Larsson
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Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer
Genes, Chromosomes and Cancer, 2005AbstractGastric carcinoma is one of the most common types of cancer in Taiwan. Somatic mitochondrial DNA (mtDNA) alteration in gastric carcinoma and its association with clinicopathologic features remain unclear. When we used polymerase chain reaction (PCR) and direct sequencing, 15 of the 31 (48%) gastric carcinomas displayed somatic mutations in the ...
Chih Yi Hsu +9 more
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Mitochondrial DNA variation and cancer
Nature Reviews. Cancer, 2021P. Kopinski +4 more
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2023
Mitochondrial DNA (mtDNA) is a 16,569 base pair (bp) circular genome that is passed from generation to generation through the maternal line. mtDNA analysis in the context of the forensic science field usually involves unidentified human remains or missing persons. These cases tend to have more challenging sample types (e.g., rootless hairs, bone, blood,
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Mitochondrial DNA (mtDNA) is a 16,569 base pair (bp) circular genome that is passed from generation to generation through the maternal line. mtDNA analysis in the context of the forensic science field usually involves unidentified human remains or missing persons. These cases tend to have more challenging sample types (e.g., rootless hairs, bone, blood,
openaire +2 more sources
Dating of the human-ape splitting by a molecular clock of mitochondrial DNA
Journal of Molecular Evolution, 2005M. Hasegawa, H. Kishino, T. Yano
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The Netherlands Journal of Medicine, 1998
Douglas M. Turnbull, Patrick F. Chinnery
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Douglas M. Turnbull, Patrick F. Chinnery
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Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy
Nature Immunology, 2020T. Yamazaki +14 more
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