Results 161 to 170 of about 861,247 (242)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Metagenomic Analysis of Wild Apple (<i>Malus sieversii</i>) Trees from Natural Habitats of Kazakhstan. [PDF]

Plants (Basel)
Mendybayeva A, Makhambetov A, Yanin K, Taskuzhina A, Khusnitdinova M, Gritsenko D.   +5 more
europepmc   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

DNA Methylation and Alternative Splicing Safeguard Genome and Transcriptome After a Retrotransposition Burst in <i>Arabidopsis thaliana</i>. [PDF]

Int J Mol Sci
Merkulov P, Latypova A, Tiurin K, Serganova M, Kirov I.   +4 more
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Comparative transcriptomics of transgenic tobacco plants overexpressing Miscanthus sinensis BTF3. [PDF]

BMC Genomics
Seo JW, Ham DY, Lee JG, Kim HY, Choi IY, Kim MJ, Seong ES.   +6 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Reference Gene-Assisted LAMP-LFD for Sensitive and Specific Detection of Soy DNA as a Marker for Allergen Presence in Complex Food Products. [PDF]

J Agric Food Chem
Li Q, Voorhuijzen-Harink MM, Han D, Fronen BJ, Hoof RV, Chen M, Wang Z, Bovee TFH, Gao Z, Salentijn GI.   +9 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Rapid and Efficient DNA Extraction Protocol from Peruvian Native Cotton (<i>Gossypium barbadense</i> L.) Lambayeque, Peru. [PDF]

Methods Protoc
Lopez LMS, Gonzales HL, Garcia WEV, de Jesus Velez Chicoma RL, Greta MC.   +4 more
europepmc   +1 more source