Results 191 to 200 of about 3,781,819 (347)

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

BEN: a novel domain in chromatin factors and DNA viral proteins

Bioinform., 2008
S. Abhiman, L. Iyer, L. Aravind
semanticscholar   +1 more source

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

Advanced Healthcare Materials, EarlyView.
This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale, Deborah Stanco, Roberta Visone, Bernd Stadlinger, Pierfrancesco Pagella, Marco Rasponi, Thimios A. Mitsiadis   +6 more
wiley   +1 more source

Dynamics of the DNA Viral Community in Korean Coastal Waters. [PDF]

Sci Data
Kim YJ, Kim KE, Kim HJ, Park JS, Kim MJ, Kim SM, Lee T, Jung SW.   +7 more
europepmc   +1 more source

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo

Cell Research, 2017
Chao Jiang, Miao Mei, Bin Li, Xiurui Zhu, Wenhong Zu, Yujie Tian, Qiannan Wang, Yong Guo, Yizhou Dong, Xu Tan   +9 more
semanticscholar   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

DNA viral community enhances microbial carbon fixation capacity via auxiliary metabolic genes in contaminated soils. [PDF]

Nat Commun
Lu JN, Chao Y, Tian L, Zhong X, Chen Z, He H, Huang B, Li M, Feng Z, Feng H, Hu C, Zhou S, Zhang L, Yang Y, Ruan Z, Ding K, Yang Y, Yuan K, Liu W, Qi H, Cao Y, Fei YH, Ling N, Wang S, Tang YT, Luan T, Xu Z, Qiu R.   +27 more
europepmc   +1 more source

BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients.

Blood, 2005
V. Erard, H. Kim, L. Corey, A. Limaye, Meei-Li W Huang, D. Myerson, Chris Davis, M. Boeckh   +7 more
semanticscholar   +1 more source

Studies on the Biosynthesis of Viral DNA

Cold Spring Harbor Symposia on Quantitative Biology, 1962
openaire   +2 more sources