Results 1 to 10 of about 1,502,813 (305)
Kinds of Replication: Examining the Meanings of “Conceptual Replication” and “Direct Replication” [PDF]
Perspectives on Psychological Science, 2022 Although psychology’s recent crisis has been attributed to various scientific practices, it has come to be called a “replication crisis,” prompting extensive appraisals of this putatively crucial scientific practice. These have yielded disagreements over what kind of replication is to be preferred and what phenomena are being explored, yet the ...
Maarten Derksen, Jill Morawski
openaire +2 more sources
Viruses, 2021 Development of potential HIV-1 curative interventions requires accurate characterization of the proviral reservoir, defined as host-integrated viral DNA genomes that drive rebound of viremia upon halting ART (antiretroviral therapy).
Sean C. Patro +3 more
doaj +1 more source
The Role of Capsid in HIV-1 Nuclear Entry
Viruses, 2021 HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration.
Anabel Guedán +3 more
doaj +1 more source
Viruses, 2021 Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target proviral populations in cells that persist for prolonged periods and that can undergo clonal expansion.
Chuen-Yen Lau +2 more
doaj +1 more source
MTBP phosphorylation controls DNA replication origin firing
Scientific Reports, 2021 Faithful genome duplication requires regulation of origin firing to determine loci, timing and efficiency of replisome generation. Established kinase targets for eukaryotic origin firing regulation are the Mcm2-7 helicase, Sld3/Treslin/TICRR and Sld2 ...
Pedro Ferreira +12 more
doaj +1 more source
Viruses, 2021 The 3C-like protease (3CLpro) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases.
Jonathan M. O. Rawson +4 more
doaj +1 more source
mBio, 2021 Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon +9 more
doaj +1 more source
Replicating replicability modeling of psychology papers [PDF]
Proceedings of the National Academy of Sciences, 2023 Youyou et al. (1) estimated the replicability of more than 14,000 psychology papers using a machine learning model, trained on main texts of 388 replicated studies. The authors identified mean replicability scores of psychological subfields. They also verified the causality of the model predictions; correlations between model predictions and study ...
Aske Mottelson, Dimosthenis Kontogiorgos
openaire +3 more sources
Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication
mBio, 2022 Frequent recombination is a hallmark of retrovirus replication. In rare cases, recombination occurs between distantly related retroviruses, generating novel viruses that may significantly impact viral evolution and public health.
Jonathan M. O. Rawson +10 more
doaj +1 more source
eLife, 2015 We have reconstituted a eukaryotic leading/lagging strand replisome comprising 31 distinct polypeptides. This study identifies a process unprecedented in bacterial replisomes.
Roxana E Georgescu +7 more
doaj +1 more source