Results 1 to 10 of about 151,651 (216)
New insights into retroviral Gag–Gag and Gag–membrane interactions [PDF]
Frontiers in Microbiology, 2014 A critical aspect of viral replication is the assembly of virus particles, which are subsequently released as progeny virus. While a great deal of attention has been focused on better understanding this phase of the viral life cycle, many aspects of the molecular details remain poorly understood.
Maldonado, José O. +4 more
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Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice [PDF]
Viruses, 2021 Immature HIV virions harbor a lattice of Gag molecules with significant ordering in CA-NTD, CA-CTD and SP1 regions. This ordering plays a major role during HIV maturation. To test the condition in which the Gag lattice forms in vivo, we assembled virus like particles (VLPs) by expressing only HIV Gag in mammalian cells.
Ipsita Saha +8 more
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Molecular Cell, 2004 The Polycomb group (PcG) complex mediates heritable silencing of numerous genes during development. In a recent issue of Molecular Cell, Wang et al. (2004) characterize the order of PcG protein recruitment to specific regions of Ubx and substantiate a binding-in trans looping model of repression that may interfere with transcription initiation or ...
openaire +2 more sources
JAMA: The Journal of the American Medical Association, 1918 With the exception of the device for opening the arms, this gag is the same as the Jennings mouth gag, except that it is perhaps a bit stronger. I have done away with the somewhat complicated machinery for opening and shutting the mouth gag, as devised by Jennings, and have employed a method similar to the one I suggested many years ago for my mastoid ...
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Role of RNA in Facilitating Gag/Gag-Pol Interaction [PDF]
Journal of Virology, 2002 ABSTRACT We have examined the influence of RNA upon the interaction of Gag-Pol with Gag during human immunodeficiency virus type 1 (HIV-1) assembly. COS7 cells were transfected with protease-negative HIV-1 proviral DNA, and Gag/Gag-Pol complexes were detected by coimmunoprecipitation with anti-integrase.
Ahmad, Khorchid +3 more
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source