New Insights Into Retroviral Gag-Gag and Gag-Membrane Interactions [PDF]
Frontiers in Microbiology, 2014 A critical aspect of viral replication is the assembly of virus particles, which aresubsequently released as progeny virus. While a great deal of attention has beenfocused on better understanding this phase of the viral life cycle, many aspects of ...
Jose eMaldonado +4 more
doaj +5 more sources
Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice [PDF]
Viruses, 2021 Immature HIV virions harbor a lattice of Gag molecules with significant ordering in CA-NTD, CA-CTD and SP1 regions. This ordering plays a major role during HIV maturation. To test the condition in which the Gag lattice forms in vivo, we assembled virus like particles (VLPs) by expressing only HIV Gag in mammalian cells.
Ipsita Saha +8 more
openaire +5 more sources
Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity [PDF]
Retrovirology, 2017 Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 ...
Kazuaki Monde +6 more
doaj +3 more sources
DISTINCTIVE SIRE1 RETROTRANSPOSON PATTERNS ON BARLEY CHROMOSOMES?
Trakya University Journal of Natural Sciences, 2021 SIRE1 is an active and relatively high copy-number retroelement belongs to the Tyl/Copia long terminal repeat (LTR) retrotransposon superfamily. Distinctive SIRE1 elements (ENV and GAG) distributions in barley genome were observed by using fluorescent in
Nermin Gozukirmizi, Elif Karlık
doaj +1 more source
Microbiology Spectrum, 2022 TRIM5α polymorphism in rhesus macaques (RM) limits the genetic pool of animals in which we can perform simian immunodeficiency virus (SIV) studies without first screening animals for permissive TRIM5α genotypes.
Cheri A. Lee, Vanessa M. Hirsch
doaj +1 more source
Analysing the HERV-K env, np9, rec and gag expression in cervical tissues
New Microbes and New Infections, 2021 Cervical cancer is considered to be the fourth common cancer. It is assumed that numerous risk factors, especially infectious ones, can have a detrimental effect on cervical cancer.
S. Tavakolian +3 more
doaj +1 more source
Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity
Viruses, 2021 Host plasma membrane protein SERINC5 is incorporated into budding retrovirus particles where it blocks subsequent entry into susceptible target cells.
William E. Diehl +6 more
doaj +1 more source
Frontiers in Immunology, 2022 Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) formulation expressing HIV-1 Gag and Gag conserved regions (CE) as immunogens developed ...
Antonio Valentin +17 more
doaj +1 more source
N-terminally myristoylated feline foamy virus Gag allows Env-independent budding of sub-viral particles [PDF]
, 2011 Foamy viruses (FVs) are distinct retroviruses classified as Spumaretrovirinae in contrast to the other retroviruses, the Orthoretrovirinae. As a unique feature of FVs, Gag is not sufficient for sub-viral particle (SVP) release. In primate and feline FVs (
Löchelt, Martin +5 more
core +1 more source
Gag-specific PCR and binding antibody assay in CD4+ T lymphocyte depleted CMV-seropositive rhesus macaque dams that received RhCMV FL-RhCMVΔRh13.1/SIVgag. [PDF]
, 2023 (A) Real time PCR for SIVgag DNA quantification performed on plasma, saliva and urine at multiple post reinfection time-points in three dams inoculated with FL-RhCMVΔRh13.1/SIVgag. Positive signal at a single time-point in KB91 saliva sample.
Anne Mirza (17101604) +17 more
core +1 more source