Results 1 to 10 of about 184,302 (307)

Perturbation of Human T-Cell Leukemia Virus Type 1 Particle Morphology by Differential Gag Co-Packaging

Viruses, 2017
Human T-cell leukemia virus type 1 (HTLV-1) is an important cancer-causing human retrovirus that has infected approximately 15 million individuals worldwide.
José O. Maldonado, Isaac Angert, Sheng Cao, Serkan Berk, Wei Zhang, Joachim D. Mueller, Louis M. Mansky   +6 more
doaj   +1 more source

HIV-1 envelope facilitates the development of protease inhibitor resistance through acquiring mutations associated with viral entry and immune escape

Frontiers in Microbiology
IntroductionThere is increasing evidence supporting a role for HIV-1 envelope in the development of Protease Inhibitor drug resistance, and a recent report from our group suggested that Env mutations co-evolve with Gag-Protease mutations in the pathway ...
Ntombikhona F. Maphumulo, Michele L. Gordon   +1 more
doaj   +1 more source

Distinct Pathway of Human T-Cell Leukemia Virus Type 1 Gag Punctum Biogenesis Provides New Insights into Enveloped Virus Assembly

mBio, 2018
The assembly of virus particles is a crucial aspect of virus spread. For retroviruses, the Gag polyprotein is the key driver for virus particle assembly.
John P. Eichorst, Yan Chen, Joachim D. Mueller, Louis M. Mansky   +3 more
doaj   +1 more source

Moloney murine leukemia virus glyco-gag facilitates xenotropic murine leukemia virus-related virus replication through human APOBEC3-independent mechanisms

Retrovirology, 2012
Background One of the unique features of gammaretroviruses is that they contain an additional extended form of Gag, glyco-gag, which initiates in the leader sequence.
Nitta Takayuki, Lee Sangouk, Ha Dat, Arias Maribel, Kozak Christine A, Fan Hung   +5 more
doaj   +1 more source

Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity

Retrovirology, 2017
Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could affect HIV-1 ...
Kazuaki Monde, Hiromi Terasawa, Yusuke Nakano, Ferri Soheilian, Kunio Nagashima, Yosuke Maeda, Akira Ono   +6 more
doaj   +1 more source

Investigating the expression of HERV-K env, np9, gag, and rec in bladder cancers

Infectious Agents and Cancer
Objective Bladder cancer (BCa) has become a growing concern worldwide, highlighting the importance of early detection and new treatment methods. Recent studies have shown that viruses from the HERV family play a significant role in the development of ...
Fariba Rafiei, Navid Masoumi, Ebrahim Faghihloo   +2 more
doaj   +1 more source

Detection of HIV-1 Genetic Variation in Gag Gene, Subtyping, and Phylogenetic Tree at Thi-Qar Province, South of Iraq

Medical Journal of Babylon
Background: HIV constitutes a major health problem for the individual and society and is a threat to public health. The World Health Organization aims to eliminate this threat by 2030.
Ahmed Hieran Ramadhan Al-Jabery, Bushra Jabbar Albadry   +1 more
doaj   +1 more source

Real-time visualization of HIV-1 GAG trafficking in infected macrophages.

PLoS Pathogens, 2008
HIV-1 particle production is driven by the Gag precursor protein Pr55(Gag). Despite significant progress in defining both the viral and cellular determinants of HIV-1 assembly and release, the trafficking pathway used by Gag to reach its site of assembly
Karine Gousset, Sherimay D Ablan, Lori V Coren, Akira Ono, Ferri Soheilian, Kunio Nagashima, David E Ott, Eric O Freed   +7 more
doaj   +1 more source

The Aspergillus fumigatus Extracellular Polysaccharide Galactosaminogalactan Displays Context-Dependent Cooperative and Competitive Social Traits in Mixed Biofilms

Journal of Fungi
Biofilm-dwelling cells construct communities by secreting extracellular polysaccharide (EPS). In bacteria, EPS can act as cooperative public goods or competitive traits, yet the social nature of EPS in fungi remains poorly understood ...
Longyun Cong, Yufei Zhang, Hua Chen, Ruiyang Lu, Shizhu Zhang   +4 more
doaj   +1 more source

HIV-1 Vpr Abrogates the Effect of TSG101 Overexpression to Support Virus Release.

PLoS ONE, 2016
HIV-1 budding requires interaction between Gag and cellular TSG101 to initiate viral particle assembly and release via the endosomal sorting complexes required for transport (ESCRT) pathway.
Nopporn Chutiwitoonchai, Lowela Siarot, Eri Takeda, Tatsuo Shioda, Motoki Ueda, Yoko Aida   +5 more
doaj   +1 more source