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Hepatitis C Virus Assembly Imaging [PDF]
Viruses, 2011 Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process ...
Costin-Ioan Popescu +2 more
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Structure of SARS-CoV-2 membrane protein essential for virus assembly [PDF]
Nature Communications, 2022 M protein plays essential roles in virus assembly and morphogenesis. Here, authors reveal two cryo-EM structures of M protein from SARS-CoV-2 that suggest conformational dynamics of M protein and its role in virus assembly.
Zhikuan Zhang +13 more
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Influenza virus assembly and budding
Virology, 2011 Influenza A virus causes seasonal epidemics, sporadic pandemics and is a significant global health burden. Influenza virus is an enveloped virus that contains a segmented negative strand RNA genome. Assembly and budding of progeny influenza virions is a complex, multi-step process that occurs in lipid raft domains on the apical membrane of infected ...
Jeremy S Rossman, Robert Lamb
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Hepatitis C Virus: Assembly and Release of Virus Particles [PDF]
Journal of Biological Chemistry, 2010 Hepatitis C virus is a blood-borne virus that typically establishes a chronic infection in the liver, which often results in cirrhosis and hepatocellular carcinoma. Progress in understanding the complete virus life cycle has been greatly enhanced by the recent availability of a tissue culture system that produces infectious virus progeny.
Daniel M Jones
exaly +3 more sources
Hepatitis E Virus Assembly and Release. [PDF]
Viruses, 2019 Hepatitis E is an underestimated threat to public health, caused by the hepatitis E virus (HEV). HEV is the most common cause of acute viral hepatitis in the world, with no available direct-acting antiviral treatment. According to a recent WHO report, 20 million people become infected with HEV annually, resulting in 44,000 deaths.
Ju X, Ding Q.
europepmc +5 more sources
Trafficking of hepatitis C virus core protein during virus particle assembly.
PLoS Pathogens, 2011 Hepatitis C virus (HCV) core protein is directed to the surface of lipid droplets (LD), a step that is essential for infectious virus production. However, the process by which core is recruited from LD into nascent virus particles is not well understood.
Natalie A Counihan +2 more
doaj +3 more sources
Frontiers in Microbiology, 2021 Flavivirus envelope protein (E) plays an important role in cellular infection, especially in virulence and antigenicity. E domain III of Tembusu virus (TMUV) is highly conserved among flaviviruses and contains four loop regions. However, the functions of
Tao Hu +50 more
doaj +1 more source
Rotavirus Particle Disassembly and Assembly In Vivo and In Vitro
Viruses, 2023 Rotaviruses (RVs) are non-enveloped multilayered dsRNA viruses that are major etiologic agents of diarrheal disease in humans and in the young in a large number of animal species.
Dunia Asensio-Cob +2 more
doaj +1 more source
The curious case of genome packaging and assembly in RNA viruses infecting plants
Frontiers in Genetics, 2023 Genome packaging is the crucial step for maturation of plant viruses containing an RNA genome. Viruses exhibit a remarkable degree of packaging specificity, despite the probability of co-packaging cellular RNAs.
Tushar Ranjan +9 more
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Mechanisms of Virus Assembly [PDF]
Annual Review of Physical Chemistry, 2015 Viruses are nanoscale entities containing a nucleic acid genome encased in a protein shell called a capsid and in some cases are surrounded by a lipid bilayer membrane. This review summarizes the physics that govern the processes by which capsids assemble within their host cells and in vitro.
Perlmutter, Jason D, Hagan, Michael F
openaire +3 more sources