Results 21 to 30 of about 488,085 (295)

In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus. [PDF]

, 2016
Packaging of the genome into a protein capsid and its subsequent delivery into a host cell are two fundamental processes in the life cycle of a virus. Unlike double-stranded DNA viruses, which pump their genome into a preformed capsid, single-stranded ...
Dai, Xinghong, Du, Yushen, Lai, Mason, Li, Zhihai, Shu, Sara, Sun, Ren, Zhou, Z Hong   +6 more
core   +1 more source

Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain [PDF]

, 2012
Segment 7 of influenza A virus produces up to four mRNAs. Unspliced transcripts encode M1, spliced mRNA2 encodes the M2 ion channel, while protein products from spliced mRNAs 3 and 4 have not previously been identified.
Digard, Paul, Firth, Andrew E., Fodor, Ervin, Gog, Julia R., Hutchinson, Edward C., Jagger, Brett W., Kang, Zi H., Kash, John C., Robb, Nicole, Schwartzman, Louis M., Stuart, Amanda D., Taubenberger, Jeffery K., Wise, Helen M.   +12 more
core   +4 more sources

Alterations of membrane curvature during influenza virus budding [PDF]

, 2014
Influenza A virus belongs to the Orthomyxoviridae family. It is an enveloped virus that contains a segmented and negative-sense RNA genome. Influenza A viruses cause annual epidemics and occasional major pandemics, are a major cause of morbidity and ...
Agnieszka Martyna, Ali, Brown, Bruce, Chen, Enami, Gomez-Puertas, Jeremy Rossman, Johnson, Lai, Leser, Liao, Liu, McCown, McCown, Palese, Pattnaik, Pinto, Rossman, Rossman, Rossman, Rossman, Ruigrok, Schmidt, Takeda, Wang, Wang, Watanabe, Zebedee, Zhang   +29 more
core   +1 more source

Dual Role of a Viral Polymerase in Viral Genome Replication and Particle Self-Assembly

mBio, 2018
Double-stranded RNA (dsRNA) viruses package several RNA-dependent RNA polymerases (RdRp) together with their dsRNA genome into an icosahedral protein capsid known as the polymerase complex.
Xiaoyu Sun, Serban L. Ilca, Juha T. Huiskonen, Minna M. Poranen   +3 more
doaj   +1 more source

Distinct Pathway of Human T-Cell Leukemia Virus Type 1 Gag Punctum Biogenesis Provides New Insights into Enveloped Virus Assembly

mBio, 2018
The assembly of virus particles is a crucial aspect of virus spread. For retroviruses, the Gag polyprotein is the key driver for virus particle assembly.
John P. Eichorst, Yan Chen, Joachim D. Mueller, Louis M. Mansky   +3 more
doaj   +1 more source

Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection [PDF]

, 2011
Copyright © 2012, American Society for Microbiology. All Rights ReservedThe influenza A virus M2 ion channel protein has the longest cytoplasmic tail (CT) among the three viral envelope proteins and is well conserved between different viral strains.
B. Nal, Barman, Barman, Bruce, Carlton, Chen, Chen, Chen, Cheung, Ciampor, Compans, Creutz, Cubells, Eierhoff, Enrich, F. Kien, Formstecher, Fromont-Racine, Gannagé, Gerke, Goswami, Grantham, Guan, Gujuluva, H. Ma, Harris, Hartshorn, Henkel, Hoffmann, Holsinger, Honda, Hui, Ichinohe, Iwatsuki-Horimoto, K. S. Tse, L. L. M. Poon, Lakadamyali, Lamb, Lamb, Lee, Li, Liu, M. Maniere, McCown, McCown, Monastyrskaya, N. Lagarde, Nayak, Nefkens, Noton, Palese, Pinto, Pinto, Pinto, Pleschka, Rossman, Rossman, Rossman, Scheiffele, Simpson-Holley, Smythe, Sun, Thaa, Thomas, Ueda, Vila de Muga, Wang, Wang, Welsch, Y. Zhang   +69 more
core   +2 more sources

The Revisited Genome of Bacillus subtilis Bacteriophage SPP1

Viruses, 2018
Bacillus subtilis bacteriophage SPP1 is a lytic siphovirus first described 50 years ago. Its complete DNA sequence was reported in 1997. Here we present an updated annotation of the 44,016 bp SPP1 genome and its correlation to different steps of the ...
Lia M. Godinho, Mehdi El Sadek Fadel, Céline Monniot, Lina Jakutyte, Isabelle Auzat, Audrey Labarde, Karima Djacem, Leonor Oliveira, Rut Carballido-Lopez, Silvia Ayora, Paulo Tavares   +10 more
doaj   +1 more source

Human Cytomegalovirus Egress: Overcoming Barriers and Co-Opting Cellular Functions

Viruses, 2021
The assembly of human cytomegalovirus (HCMV) and other herpesviruses includes both nuclear and cytoplasmic phases. During the prolonged replication cycle of HCMV, the cell undergoes remarkable changes in cellular architecture that include marked ...
Veronica Sanchez, William Britt
doaj   +1 more source

Virus assembly, allostery and antivirals [PDF]

Trends in Microbiology, 2011
Assembly of virus capsids and surface proteins must be regulated to ensure that the resulting complex is an infectious virion. In this review, we examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of glycoproteins in the alphaviruses.
Zlotnick, Adam, Mukhopadhyay, Suchetana
openaire   +2 more sources

HIV‐1 matrix domain removal ameliorates virus assembly and processing defects incurred by positive nucleocapsid charge elimination

FEBS Open Bio, 2015
Human immunodeficiency virus type 1 nucleocapsid (NC) basic residues presumably contribute to virus assembly via RNA, which serves as a scaffold for Gag–Gag interaction during particle assembly.
Li-Jung Ko, Fu-Hsien Yu, Kuo-Jung Huang, Chin-Tien Wang   +3 more
doaj   +1 more source