Results 11 to 20 of about 2,979,740 (254)

Reduced expression of human metapneumovirus matrix protein impacts virus assembly and ribonucleoprotein localization [PDF]

Journal of Virology
Human metapneumovirus (HMPV) causes severe respiratory tract infections in all cohorts, particularly in vulnerable groups such as children, older adults, and the immunocompromised.
Chase Jordan Heim, David Adam Stein, Hong M. Moulton, Emilia Galperin, Rebecca Ellis Dutch   +4 more
doaj   +2 more sources

Coronavirus membrane protein with a fluorescent protein tag enables particle tracking for the study of virus assembly and egress in live cells [PDF]

Journal of Virology
Coronavirus particles assemble at endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes and exit from host cells via secretory organelles that are not well defined.
Bereket Stefanos, Noe R. B. Green, Isha Nadig, Lynn A. Lapierre, James R. Goldenring, Ian B. Hogue, Honor L. Glenn, Brenda G. Hogue   +7 more
doaj   +2 more sources

Hepatitis C Virus Assembly Imaging

Viruses, 2011
Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process ...
Costin-Ioan Popescu, Yves Rouillé, Jean Dubuisson   +2 more
doaj   +2 more sources

Substitutions at Loop Regions of TMUV E Protein Domain III Differentially Impair Viral Entry and Assembly

Frontiers in Microbiology, 2021
Flavivirus envelope protein (E) plays an important role in cellular infection, especially in virulence and antigenicity. E domain III of Tembusu virus (TMUV) is highly conserved among flaviviruses and contains four loop regions. However, the functions of
Tao Hu, Zhen Wu, Shaoxiong Wu, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Dekang Zhu, Dekang Zhu, Dekang Zhu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Sai Mao, Sai Mao, Sai Mao, Xumin Ou, Xumin Ou, Xumin Ou, Qun Gao, Qun Gao, Qun Gao, Di Sun, Di Sun, Di Sun, Yunya Liu, Ling Zhang, YanLing Yu, Shun Chen, Shun Chen, Shun Chen, Anchun Cheng, Anchun Cheng, Anchun Cheng   +50 more
doaj   +1 more source

Rotavirus Particle Disassembly and Assembly In Vivo and In Vitro

Viruses, 2023
Rotaviruses (RVs) are non-enveloped multilayered dsRNA viruses that are major etiologic agents of diarrheal disease in humans and in the young in a large number of animal species.
Dunia Asensio-Cob, Javier M. Rodríguez, Daniel Luque   +2 more
doaj   +1 more source

The curious case of genome packaging and assembly in RNA viruses infecting plants

Frontiers in Genetics, 2023
Genome packaging is the crucial step for maturation of plant viruses containing an RNA genome. Viruses exhibit a remarkable degree of packaging specificity, despite the probability of co-packaging cellular RNAs.
Tushar Ranjan, Ravi Ranjan Kumar, Mohammad Ansar, Jitesh Kumar, Auroshikha Mohanty, Anamika Kumari, Khushbu Jain, Kumari Rajani, Sailabala Dei, Mohammad Feza Ahmad   +9 more
doaj   +1 more source

RNA packaging and uncoating in simple single-stranded RNA viruses [PDF]

, 2012
Simple (non-enveloped) small, positive-sense single-stranded RNA viruses infect hosts from all kingdoms of life. However, their assembly and uncoating processes remain poorly understood. For turnip crinkle virus (TCV), 3D reconstructions by cryoelectron
Bakker, Saskia
core   +5 more sources

Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane

Viruses, 2020
Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host ...
Kaveesha J. Wijesinghe, Luke McVeigh, Monica L. Husby, Nisha Bhattarai, Jia Ma, Bernard S. Gerstman, Prem P. Chapagain, Robert V. Stahelin   +7 more
doaj   +1 more source

Structural Assembly of Qβ Virion and Its Diverse Forms of Virus-like Particles

Viruses, 2022
The coat proteins (CPs) of single-stranded RNA bacteriophages (ssRNA phages) directly assemble around the genomic RNA (gRNA) to form a near-icosahedral capsid with a single maturation protein (Mat) that binds the gRNA and interacts with the retractile ...
Jeng-Yih Chang, Karl V. Gorzelnik, Jirapat Thongchol, Junjie Zhang   +3 more
doaj   +1 more source

Alphavirus Particles Can Assemble with an Alternate Triangulation Number

Viruses, 2022
Alphaviruses are spherical, enveloped RNA viruses primarily transmitted by mosquitoes, and cause significant arthritogenic and neurotropic disease in humans and livestock.
Jason T. Kaelber, David Chmielewski, Wah Chiu, Albert J. Auguste   +3 more
doaj   +1 more source