Results 1 to 10 of about 3,096,391 (336)

IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion

bioRxiv, 2023
Interferon-induced transmembrane protein 3 (IFITM3) inhibits the entry of numerous viruses through undefined molecular mechanisms. IFITM3 localizes in the endosomal-lysosomal system and specifically impacts virus fusion with target cell membranes.
Steffen Klein, Gonen Golani, Fabio Lolicato, Carmen Lahr, D. Beyer, Alexia Herrmann, Moritz Wachsmuth-Melm, Nina Reddmann, Romy Brecht, Mehdi Hosseinzadeh, Androniki Kolovou, Jana Makroczyová, Sarah Peterl, Martin Schorb, Y. Schwab, B. Brügger, W. Nickel, U. Schwarz, P. Chlanda   +18 more
semanticscholar   +1 more source

The Immunomodulatory CEA Cell Adhesion Molecule 6 (CEACAM6/CD66c) Is a Protein Receptor for the Influenza A Virus

Viruses, 2021
To establish a productive infection in host cells, viruses often use one or multiple host membrane glycoproteins as their receptors. For Influenza A virus (IAV) such a glycoprotein receptor has not been described, to date.
Shah Kamranur Rahman, Mairaj Ahmed Ansari, Pratibha Gaur, Imtiyaz Ahmad, Chandrani Chakravarty, Dileep Kumar Verma, Anshika Sharma, Sanjay Chhibber, Naila Nehal, Dagmar Wirth, Sunil K. Lal   +10 more
doaj   +1 more source

Dynamics of SARS-CoV-2 Spike Proteins in Cell Entry: Control Elements in the Amino-Terminal Domains

mBio, 2021
Selective pressures drive adaptive changes in the coronavirus spike proteins directing virus-cell entry. These changes are concentrated in the amino-terminal domains (NTDs) and the receptor-binding domains (RBDs) of complex modular spike protein trimers.
Enya Qing, Tom Kicmal, Binod Kumar, Grant M. Hawkins, Emily Timm, Stanley Perlman, Tom Gallagher   +6 more
doaj   +1 more source

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Nature Communications, 2020
Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of SARS-CoV-2.
Xiuyuan Ou, Yan Liu, X. Lei, Pei Li, Dan Mi, L. Ren, Li Guo, Ruixuan Guo, Ting Chen, Jiaxin Hu, Zichun Xiang, Z. Mu, Xing Chen, Jieyong Chen, Keping Hu, Q. Jin, Jianwei Wang, Zhaohui Qian   +17 more
semanticscholar   +1 more source

Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry

mBio, 2022
The lipid composition of the host cell membrane is one of the key determinants of the entry of enveloped viruses into cells. To elucidate the detailed mechanisms behind the cell entry of rubella virus (RuV), one of the enveloped viruses, we searched for ...
Yoshio Mori, Masafumi Sakata, Shota Sakai, Toru Okamoto, Yuichiro Nakatsu, Shuhei Taguwa, Noriyuki Otsuki, Yusuke Maeda, Kentaro Hanada, Yoshiharu Matsuura, Makoto Takeda   +10 more
doaj   +1 more source

Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry

Pathogens, 2021
A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. While the world is striving for a treatment modality against SARS-CoV-2, our understanding about the virus entry mechanisms may help to design entry ...
Rahul K. Suryawanshi, Chandrashekhar D. Patil, Raghuram Koganti, Sudhanshu Kumar Singh, Joshua M. Ames, Deepak Shukla   +5 more
doaj   +1 more source

Different infectivity of HIV-1 strains is linked to number of envelope trimers required for entry. [PDF]

PLoS Pathogens, 2015
HIV-1 enters target cells by virtue of envelope glycoprotein trimers that are incorporated at low density in the viral membrane. How many trimers are required to interact with target cell receptors to mediate virus entry, the HIV entry stoichiometry ...
Oliver F Brandenberg, Carsten Magnus, Peter Rusert, Roland R Regoes, Alexandra Trkola   +4 more
doaj   +1 more source

Envelope Protein Ubiquitination Drives Zika Virus Entry and Pathogenesis

Nature, 2020
Zika virus (ZIKV) belongs to the family Flaviviridae, and is related to other viruses that cause human diseases. Unlike other flaviviruses, ZIKV infection can cause congenital neurological disorders and replicates efficiently in reproductive tissues1–3 ...
M. Giraldo, Hongjie Xia, L. Aguilera-Aguirre, Adam Hage, Sarah van Tol, Chao Shan, Xuping Xie, Gail L. Sturdevant, S. Robertson, K. McNally, Kimberly Meade-White, Sasha R. Azar, S. Rossi, W. Maury, M. Woodson, H. Ramage, Jeffrey R. Johnson, N. Krogan, M. Morais, S. Best, P. Shi, Ricardo Rajsbaum   +21 more
semanticscholar   +1 more source

Hepatitis B Virus Entry into Cells

Cells, 2020
Hepatitis B virus (HBV), an enveloped partially double-stranded DNA virus, is a widespread human pathogen responsible for more than 250 million chronic infections worldwide.
Charline Herrscher, P. Roingeard, Emmanuelle Blanchard   +2 more
semanticscholar   +1 more source

African Swine Fever Virus Protein pE199L Mediates Virus Entry by Enabling Membrane Fusion and Core Penetration

mBio, 2020
African swine fever virus (ASFV) causes a highly lethal swine disease that is currently present in many countries of Eastern Europe, the Russian Federation, and Southeast Asia, severely affecting the pig industry.
Tania Matamoros, A. Alejo, Javier M Rodríguez, B. Hernáez, Milagros Guerra, A. Fraile-Ramos, G. Andrés   +6 more
semanticscholar   +1 more source