Results 41 to 50 of about 598,389 (302)

Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

Nature Communications, 2020
The mechanism underlying the cellular entry of Zika virus is not fully understood. Here, the authors use a chemically modified virus and time-resolved proteomics to capture interacting host proteins during virus entry and identify NCAM1 as a ZIKV ...
Mayank Srivastava, Ying Zhang, Jian Chen, Devika Sirohi, Andrew Miller, Yang Zhang, Zhilu Chen, Haojie Lu, Jianqing Xu, Richard J. Kuhn, W. Andy Tao   +10 more
doaj   +1 more source

Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry [PDF]

, 2006
Affiliation: Département de microbiologie et immunologie, Faculté de médecine, Université de Montréal & Institut de Recherches Cliniques de MontréalBACKGROUND:Human immunodeficiency virus (HIV) enters target cells by a membrane fusion process that ...
Bourgeois, Rachel, Mercier, Johanne, Paquette-Brooks, Isabelle, Cohen, Éric A.   +3 more
core   +3 more sources

Bluetongue Virus Entry into Cells [PDF]

Journal of Virology, 2007
ABSTRACT Bluetongue virus (BTV) is a member of the Orbivirus genus within the Reoviridae family. Like those of other members of the family, BTV particles are nonenveloped and contain two distinct capsids, namely, an outer capsid and an inner capsid or core. The two outer
FORZAN, MARIO, M. Marsh, P. Roy
openaire   +4 more sources

Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors [PDF]

, 2010
Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined.
Bitzegeio, Julia, Bankwitz, Dorothea, Hueging, Kathrin, Haid, Sibylle, Brohm, Christiane, Zeisel, Mirjam B., Herrmann, Eva, Iken, Marcus, Ott, Michael, Baumert, Thomas, Pietschmann, Thomas   +10 more
core   +2 more sources

HSPA4 Enhances BRSV Entry via Clathrin-Mediated Endocytosis Through Regulating the PI3K–Akt Signaling Pathway and ATPase Activity of HSC70

Viruses
Bovine respiratory syncytial virus (BRSV) is an enveloped RNA virus that utilizes clathrin-mediated endocytosis for cell entry and is a significant pathogen in bovine respiratory disease (BRD).
Yang Liu, Qiongyi Li, Shuai Shao, Xiaolan Ji, Wanning Gao, Yiyang Fan, Mingqi Liu, Yan Wang, Jialin Bai   +8 more
doaj   +1 more source

Elucidating virus entry using a tetracysteine-tagged virus [PDF]

Methods, 2017
Fluorescent tags constitute an invaluable tool in facilitating a deeper understanding of the mechanistic processes governing virus-host interactions. However, when selecting a fluorescent tag for in vivo imaging of cells, a number of parameters and aspects must be considered.
Mohl, Bjorn-Patrick, Roy, Polly
openaire   +2 more sources

Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein [PDF]

, 2018
We have produced a new Ebola virus pseudotype: E-S-FLU, which can be handled in biosafety level-1/2 containment for laboratory analysis. E-S-FLU is a single cycle influenza virus coated with Ebolavirus glycoprotein, and it encodes enhanced green ...
Annaert, Wim, Rijal, Pramila, Schimanski, Lisa, Tharkeshwar, Arun Kumar, Townsend, Alain, Wright, Edward, Xiao, Julie   +6 more
core   +1 more source

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating

mBio, 2020
While the basic mechanisms of flavivirus entry and fusion are understood, little is known about the postfusion events that precede RNA replication, such as nucleocapsid disassembly. We describe here a sensitive, conditionally replication-defective yellow
Harish N. Ramanathan, Shuo Zhang, Florian Douam, Katrina B. Mar, Jinhong Chang, Priscilla L. Yang, John W. Schoggins, Alexander Ploss, Brett D. Lindenbach   +8 more
doaj   +3 more sources

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Characterization of dengue virus entry into HepG2 cells [PDF]

, 2009
Background Despite infections by the dengue virus being a significant problem in tropical and sub-tropical countries, the mechanism by which the dengue virus enters into mammalian cells remains poorly described.
Lukkana Suksanpaisan, Tharinee Susantad, Duncan R Smith   +2 more
core   +2 more sources