Results 61 to 70 of about 304,283 (159)

ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly

eLife, 2019
Oncogenic human papillomaviruses (HPV) are small DNA viruses that infect keratinocytes. After HPV binding to cell surface receptors, a cascade of molecular interactions mediates the infectious cellular internalization of virus particles.
Snježana Mikuličić, Jérôme Finke, Fatima Boukhallouk, Elena Wüstenhagen, Dominik Sons, Yahya Homsi, Karina Reiss, Thorsten Lang, Luise Florin   +8 more
doaj   +1 more source

Explorations on the antiviral potential of zinc and magnesium salts against chikungunya virus: implications for therapeutics

Frontiers in Cellular and Infection Microbiology
BackgroundChikungunya virus (CHIKV), which causes chikungunya fever, is an arbovirus of public health concern with no approved antiviral therapies. A significant proportion of patients develop chronic arthritis after an infection.
Kusuma Sai Davuluri, Shridhar Shukla, Mahadeo Kakade, Sarah Cherian, Sarah Cherian, Kalichamy Alagarasu, Kalichamy Alagarasu, Deepti Parashar, Deepti Parashar   +8 more
doaj   +1 more source

Molecular Mechanisms of Ebola Virus Entry into Permissive Cells

Проблемы особо опасных инфекций, 2015
Ebola virus, representative of the Ebolavirus genus, Filoviridae family, causes severe hemorrhagic fever in humans, with lethality rates amounting up to 90 %. The members of Ebolavirus genus infect a broad range of mammalian cells.
T. E. Sizikova, V. N. Lebedev, V. B. Pantyukhov, S. V. Borisevich   +3 more
doaj   +1 more source

The Role of Lipids in Retrovirus Replication

Viruses, 2010
Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell.
Abdul A. Waheed, Eric O. Freed
doaj   +1 more source

Syntaxin-6 restricts SARS-CoV-2 infection by facilitating virus trafficking to autophagosomes

Journal of Virology
Despite the diminishing global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus continues to circulate and undergo mutations, posing ongoing challenges for public health.
Hao Sun, Qi Yang, Yecheng Zhang, Saisai Cui, Zhe Zhou, Peilu Zhang, Lijia Jia, Mingxia Zhang, Yun Wang, Xinwen Chen, Rongjuan Pei   +10 more
doaj   +1 more source

Ex vivo HIV entry into blood CD4+ T cells does not predict heterosexual HIV acquisition in women.

PLoS ONE, 2018
BackgroundA blood-based assay that could quantify HIV susceptibility would be very valuable for HIV prevention research. Previously, we developed and validated an ex vivo, flow-based, HIV entry assay to assess genital HIV susceptibility in endocervical ...
Vineet Joag, Aida Sivro, Nonhlanhla Yende-Zuma, Hajra Imam, Natasha Samsunder, Quarraisha Abdool Karim, Salim Abdool Karim, Lyle McKinnon, Rupert Kaul   +8 more
doaj   +1 more source

Selective autophagy impedes KSHV entry after recruiting the membrane damage sensor galectin-8 to virus-containing endosomes

Cell Reports
Summary: Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus. Autophagy during KSHV entry has remained unexplored. We show that LC3 lipidation as a hallmark of autophagy is induced shortly after KSHV entry.
Katarina Wendy Schmidt, Charlotte Montespan, Danielle Thompson, Miriam S. Lucas, Laure-Anne Ligeon, Harald Wodrich, Alexander S. Hahn, Urs F. Greber, Christian Münz   +8 more
doaj   +1 more source

Early Events in Foamy Virus—Host Interaction and Intracellular Trafficking

Viruses, 2013
Here we review viral and cellular requirements for entry and intracellular trafficking of foamy viruses (FVs) resulting in integration of viral sequences into the host cell genome.
Dirk Lindemann, Martin Volker Hamann, Ursula Berka   +2 more
doaj   +1 more source

Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins

mBio, 2016
Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers [(gp120/gp41)3] typically exist in a metastable closed conformation (state 1).
Alon Herschhorn, Xiaochu Ma, Christopher Gu, John D. Ventura, Luis Castillo-Menendez, Bruno Melillo, Daniel S. Terry, Amos B. Smith, Scott C. Blanchard, James B. Munro, Walther Mothes, Andrés Finzi, Joseph Sodroski   +12 more
doaj   +1 more source

Cell entry of hepatitis C virus

Virology, 2006
Hepatitis C virus (HCV), an important human pathogen, is an enveloped, positive-stranded RNA virus classified in the hepacivirus genus of the Flaviviridae family. Cell attachment of flaviviruses generally leads to endocytosis of bound virions. Systems that support HCV replication and particle formation in vitro are emerging only now, 16 years after the
Bartosch, Birke, Cosset, François-Loïc
openaire   +2 more sources