Results 81 to 90 of about 2,656,206 (255)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Human annexin A6 interacts with influenza A virus protein M2 and negatively modulates infection [PDF]
, 2011 The influenza A virus M2 ion channel protein has the longest cytoplasmic tail (CT) among the three viral envelope proteins and is well conserved between different viral strains.
Béatrice Nal +23 more
core +1 more source
Broad-spectrum Respiratory Virus Entry Inhibitors
, 2022 With the increasing global human population, travel and socioeconomic activities, more and more novel pathogenic viruses will emerge or re-emerge. While more than 260 viruses are known to infect humans, only a small minority of these viral diseases are ...
Zhao, H, Yuen, KY
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Molecular Mechanisms of Ebola Virus Entry into Permissive Cells
Проблемы особо опасных инфекций, 2015 Ebola virus, representative of the Ebolavirus genus, Filoviridae family, causes severe hemorrhagic fever in humans, with lethality rates amounting up to 90 %. The members of Ebolavirus genus infect a broad range of mammalian cells.
T. E. Sizikova +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Generation of a mouse model for the in vivo study of HCV-host interaction [PDF]
, 2010 The natural species tropism of hepatitis C virus (HCV) is limited to humans and higher primates. Due to the limited availability of chimpanzees, the establishment of a small-animal model for the study of HCV infection has a high priority.
D'Angelo, Fulvio
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The development of penguinpox virus (PEPV) as a vaccine vector : transfer vector construction and rescue of virus growth in rabbit kidney cells (RK-13) by vaccinia virus K1 [PDF]
, 2010 Includes bibliographical references (leaves 131-137).Of the many vaccine trials which have taken place, the most promising results have been obtained from the recent phase 3 clinical trial which tested the ability of a dual protein and Canarypox virus ...
Hu, Nai-Chung
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Syntaxin-6 restricts SARS-CoV-2 infection by facilitating virus trafficking to autophagosomes
Journal of VirologyDespite the diminishing global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus continues to circulate and undergo mutations, posing ongoing challenges for public health.
Hao Sun +10 more
doaj +1 more source
The Role of Lipids in Retrovirus Replication
Viruses, 2010 Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell.
Abdul A. Waheed, Eric O. Freed
doaj +1 more source