Results 101 to 110 of about 325,771 (306)

Comprehensive transcriptomic analysis identifies cholesterol transport pathway as a therapeutic target of porcine epidemic diarrhea coronavirus

Virus Research
Porcine epidemic diarrhea virus (PEDV) is a highly contagious virus that poses a serious threat to the global pig industry. Despite extensive efforts, the mechanism underlying virus entry for PEDV remains elusive.
Lilei Lv, Huaye Luo, Min Zhang, Chuntao Wu, Yifeng Jiang, Wu Tong, Guoxin Li, Yanjun Zhou, Yanhua Li, Zhao Wang, Changlong Liu   +10 more
doaj   +1 more source

Caveolar endocytosis and virus entry

Uirusu, 2005
The endocytic function of caveolae has been controversial for a long time. However, a real-time-imaging analysis of Simian virus 40 (SV40) 's entry in cells has indicated the existence of caveolar endocytosis during virus entry. The caveolae engulfed SV40 virions begin budding from plasma membrane depending on dynamin.
openaire   +3 more sources

Hepatitis B Virus Entry into Cells

, 2020
Hepatitis B virus (HBV), an enveloped partially double-stranded DNA virus, is a widespread human pathogen responsible for more than 250 million chronic infections worldwide.
Herrscher, Charline, Blanchard, Emmanuelle, Charline Herrscher, Emmanuelle Blanchard, Roingeard, Philippe, Philippe Roingeard   +5 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Tradeoffs in viral fitness driven by alternative entry pathways

mBio
Enveloped viruses can enter cells either through endocytosis or by direct fusion with the plasma membrane. The latter pathway often leads to syncytia formation, caused by the fusion of infected cells with neighboring receptor-bearing cells.
Marc Carrascosa-Sàez, Jérémy Dufloo, Rafael Sanjuán   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Human annexin A6 interacts with influenza A virus protein M2 and negatively modulates infection [PDF]

, 2012
The influenza A virus M2 ion channel protein has the longest cytoplasmic tail (CT) among the three viral envelope proteins and is well conserved between different viral strains.
Béatrice Nal, François Kien, Ma, H, Kien, F, Leo Lit Man Poon, Zhang, Y, Tse, KS, Poon, LLM, Maniere, M, Nadège Lagarde, Yang Zhang, Maxime Manière, Nal, B, Kong San Tse, Huailiang Ma, Lagarde, N   +15 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Autographa californica Multicapsid Nucleopolyhedrovirus efficiently infects Sf9 cells and transduces mammalian cells via direct fusion with the plasma membrane at low pH

, 2010
The budded virus (BV) of the Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) infects insect cells and transduces mammalian cells mainly through the endocytosis pathway.
F. Deng, M. Wang, Dong, S., Vlak, J.M., Deng, F., S. Dong, Wang, M., Qiu, Z., Z. Hu, Hu, Z.H., J. M. Vlak, H. Wang, Z. Qiu, Wang, H.L.   +13 more
core   +1 more source