Results 91 to 100 of about 2,750,709 (301)

Replication of Alphaviruses: A Review on the Entry Process of Alphaviruses into Cells

Advances in Virology, 2011
Alphaviruses are small, enveloped viruses, ~70 nm in diameter, containing a single-stranded, positive-sense, RNA genome. Viruses belonging to this genus are predominantly arthropod-borne viruses, known to cause disease in humans.
Jason Yat-Sing Leung, Mary Mah-Lee Ng, Justin Jang Hann Chu   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Assessment of HIV-1 entry inhibitors by MLV/HIV-1 pseudotyped vectors [PDF]

, 2005
Background: Murine leukemia virus (MLV) vector particles can be pseudotyped with a truncated variant of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) and selectively target gene transfer to human cells expressing both CD4 and an ...
Sandra Siegert, Barbara S Schnierle, Schnierle Barbara S, Wagner Ralf, Ralf Wagner, Thaler Sonja, Siegert, Sandra, Schnierle, Barbara, Siegert Sandra, Thaler, Sonja, Wagner, Ralf, Sonja Thaler   +11 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Analysis of poxvirus host cell entry by electron microscopy [PDF]

, 2013
Vaccinia virus (VACV) is the prototypic poxvirus and is complex in both composition and life cycle. In contrast to most viruses, poxviruses produce two types of infectious particles with different roles in virus dissemination: Mature virions (MVs ...
Bleck, Christopher Karl Ernst
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Comprehensive transcriptomic analysis identifies cholesterol transport pathway as a therapeutic target of porcine epidemic diarrhea coronavirus

Virus Research
Porcine epidemic diarrhea virus (PEDV) is a highly contagious virus that poses a serious threat to the global pig industry. Despite extensive efforts, the mechanism underlying virus entry for PEDV remains elusive.
Lilei Lv, Huaye Luo, Min Zhang, Chuntao Wu, Yifeng Jiang, Wu Tong, Guoxin Li, Yanjun Zhou, Yanhua Li, Zhao Wang, Changlong Liu   +10 more
doaj   +1 more source

Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail [PDF]

, 2015
A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms
Struthers, M, Tuplin, AK, Tuplin, Andrew, Bentley, K, Struthers, Madeleine, Cook, J, Cook, Jonathan, Evans, DJ, Evans, David J., Struthers, Madeline, Bentley, Kirsten, Cook, Jonathan P., Evans, David J.; id_orcid, Bentley, Kirsten; id_orcid   +13 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies.

, 2011
International audienceHepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma. Preventive modalities are absent and the current antiviral treatment is limited by resistance, toxicity, and high costs.
Isabel Fofana, Thomas F. Baumert, Samira Fafi-Kremer, Zeisel, Mirjam, B., Baumert, Thomas, F., Mirjam B. Zeisel, Fofana, Isabel, Fafi-Kremer, Samira   +7 more
core   +1 more source