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Membrane Rafts: Portals for Viral Entry
Frontiers in Microbiology, 2021 Membrane rafts are dynamic, small (10–200 nm) domains enriched with cholesterol and sphingolipids that compartmentalize cellular processes. Rafts participate in roles essential to the lifecycle of different viral families including virus entry, assembly ...
Inés Ripa +2 more
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Viral entry shapes HCMV latency establishment [PDF]
Nature CommunicationsHuman cytomegalovirus (HCMV) infection results in either productive or latent infection, the latter enabling life-long viral persistence. Monocytes support latent infection but become permissive to productive infection upon differentiation into ...
Yaarit Kitsberg +8 more
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B Cell Receptor's function in virus entry: Anti-SARS-CoV-2 B cell receptors can mediate viral entry in an ACE2-independent mechanism. [PDF]
PLoS PathogensB cells play a crucial role in humoral immunity, acting as sentinels against viral infections by using their B cell receptors (BCRs) to recognize viral proteins.
Rene Larios +12 more
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mGem: The complexity of viral entry—one virus, many receptors [PDF]
mBioBinding to cellular receptors initiates viral replication and dictates sites in the host infected by the virus. As illustrated by mammalian orthoreovirus (reovirus), viruses can bind several types of receptors using distinct capsid components to ...
Terence S. Dermody, Danica M. Sutherland
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MBio, 2019 Ebola virus (EBOV) causes highly lethal disease outbreaks against which no FDA-approved countermeasures are available. Although many host factors exploited by EBOV for cell entry have been identified, including host cell surface phosphatidylserine ...
Zachary Bornholdt +2 more
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To Include or Occlude: Rational Engineering of HCV Vaccines for Humoral Immunity
Viruses, 2021 Direct-acting antiviral agents have proven highly effective at treating existing hepatitis C infections but despite their availability most countries will not reach the World Health Organization targets for elimination of HCV by 2030.
Felicia Schlotthauer +2 more
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The Viral Capsid: A Master Key to Access the Host Nucleus
Viruses, 2021 Viruses are pathogens that have evolved to hijack the cellular machinery to replicate themselves and spread to new cells. During the course of evolution, viruses developed different strategies to overcome the cellular defenses and create new progeny ...
Guillermo Blanco-Rodriguez +1 more
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The Process of Filopodia Induction during HPV Infection
Viruses, 2022 Human Papillomavirus 16 (HPV16) infects mucosal and epithelial cells and has been identified as a high-risk HPV type that is an etiologic agent of human cancers.
Alyssa Biondo, Patricio I. Meneses
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Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration
eLife, 2020 The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are extensively glycosylated. The impact of this post-translational modification on viral entry is yet unestablished.
Qi Yang +8 more
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Viruses, 2020 Viral entry is the first stage in the virus replication cycle and, for enveloped viruses, is mediated by virally encoded glycoproteins. Viral glycoproteins have different receptor affinities and triggering mechanisms.
Maria Fernanda Lay Mendoza +4 more
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